Bell David S H
Southside Endocrinology, University of Alabama Medical School, Suite 130, 3928 Montclair Road, Birmingham, AL 35213, USA.
Case Rep Endocrinol. 2012;2012:165056. doi: 10.1155/2012/165056. Epub 2012 Dec 12.
Vitamin D deficiency has been associated with both type 1 and type 2 diabetes as well as both the microvascular and macrovascular complications of diabetes. Vitamin D deficiency has been shown to be more common in diabetic patients who have symptoms of distal symmetrical polyneuropathy. In addition, vitamin D deficiency has been associated with a lower pain threshold which increases when vitamin D deficiency is corrected. Herein, I describe a type 1 diabetic patient with neuropathic symptoms so severe that he could not work and for which he needed narcotics for pain management and whose symptoms improved dramatically with correction of the vitamin D deficiency. To my knowledge, this is the first report of an improvement in severe symptoms of diabetic neuropathy with correction of vitamin D deficiency in a single patient.
维生素D缺乏与1型和2型糖尿病以及糖尿病的微血管和大血管并发症均有关联。维生素D缺乏在有远端对称性多发性神经病变症状的糖尿病患者中更为常见。此外，维生素D缺乏与较低的疼痛阈值相关，当维生素D缺乏得到纠正时疼痛阈值会升高。在此，我描述一名1型糖尿病患者，其神经病变症状严重到无法工作，需要使用麻醉药品来控制疼痛，而随着维生素D缺乏的纠正，其症状显著改善。据我所知，这是首例关于单一患者维生素D缺乏得到纠正后糖尿病神经病变严重症状得以改善的报告。
