Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Mol Hum Reprod. 2015 May;21(5):383-8. doi: 10.1093/molehr/gav009. Epub 2015 Feb 26.
In mammals, egg activation is initiated by multiple cytosolic Ca(2+) transients (Ca(2+) oscillations) that are triggered following delivery of a putative sperm factor from the fertilizing sperm. The identity of this 'sperm factor' thus holds much significance, not only as a vital component in creating a new life, but also for its potential therapeutic and diagnostic value in human infertility. Recent data have emerged suggesting the sperm factor may be a post-acrosomal sheath WW domain-binding protein (PAWP). However, a significant body of research points to a testis-specific phospholipase C zeta (PLCζ) as the sperm factor. Herein, we examine the evidence presented in favour of PAWP in relation to PLCζ and the requisite physiological properties of the mammalian sperm factor.
在哺乳动物中，卵子激活是由多个细胞质 Ca(2+) 瞬变（Ca(2+) 震荡）引发的，这些瞬变是在受精精子中传递一个假定的精子因子后触发的。因此，这个“精子因子”的身份具有重要意义，不仅作为创造新生命的重要组成部分，而且对于人类不育症的潜在治疗和诊断价值也具有重要意义。最近的数据表明，精子因子可能是一个顶体后鞘 WW 结构域结合蛋白（PAWP）。然而，大量研究表明，精子因子是一种睾丸特异性的磷酯酶 C ζ（PLCζ）。在这里，我们研究了支持 PAWP 的证据与 PLCζ 的关系，以及哺乳动物精子因子的必要生理特性。
