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体重指数小于50kg/m²的患者行胆胰转流十二指肠转位术的安全性。

Safety of biliopancreatic diversion with duodenal switch in patients with body mass index less than 50 kg/m.

作者信息

Wang Alice, Nimeri Abdelrahman, Genz Michael, Feimster James, Thompson Kyle, Abdurakhmanov Alexander, Vijayanagar Vilok, McKillop Iain, Barbat Selwan, Kuwada Timothy, Gersin Keith S, Bauman Roc

机构信息

Department of Surgery, Wright State University, Dayton, OH, 45324, USA.

Atrium Health Weight Management, Section of Bariatric & Metabolic Surgery, Department of Surgery, Carolinas Medical Center, Atrium Health, Charlotte, NC, 28204, USA.

出版信息

Surg Endosc. 2023 Apr;37(4):3046-3052. doi: 10.1007/s00464-022-09483-5. Epub 2022 Aug 3.

Abstract

INTRODUCTION

Biliopancreatic diversion with duodenal switch (BPD-DS) has often been reserved for patients with BMI > 50 kg/m. We aim to assess the safety of BPD-DS in patients with morbid obesity (BMI 35 kg/m and < 50 kg/m) using a 150-cm common channel (CC), 150-cm Roux limb, and 60-fr bougie.

METHODS

A retrospective review was performed on patients with a BMI < 50 mg/k who underwent a BPD-DS in 2016-2019 at a single institution. Limb lengths were measured with a laparoscopic instrument with minimal tension. Sleeve gastrectomy was created with 60-fr bougie. Variables were compared using paired t test, Chi-square analysis or repeated measures ANOVA where appropriate.

RESULTS

Forty-five patients underwent BPD-DS. CC lengths and Roux limb lengths were 158 ± 20 cm and 154 ± 18 cm, respectively. Preoperative BMI was 44.9 ± 2.3 kg/m and follow-up was 2.7 ± 1.4 years. One patient required reoperation for bleeding and died from multiorgan failure and delayed sleeve leak. There was 1 (2.2%) readmission for contained anastomotic leak and 2 ED visits (4.5%) within 30 days. There were no marginal ulcers, limb length revisions, or need for parental nutrition. Percent excess weight loss was 67.2 ± 19.7%. 88.9% (N = 8), 86.6% (N = 13), and 55.5% (N = 5) of patients had resolution or improvement of their diabetes mellitus type II, hypertension, and hyperlipidemia, respectively. 40% (N = 4) of patients had resolution of their gastroesophageal reflux disease (GERD) and 11.4% (N = 5) developed de novo GERD. 32% (N = 14) of patients had vitamin D deficiency and 25% (N = 11) experienced zinc deficiency.

CONCLUSION

BPD-DS may be considered in patients with BMI < 50 kg/m with 150-cm CC, 150-cm Roux limb, and a 60-fr bougie sleeve gastrectomy. There was sustained weight loss and no protein calorie malnutrition, but Vitamin D and zinc deficiency remained a challenge. Careful patient selection and proper counseling of the risks and benefits are necessary.

摘要

引言

胆胰转流十二指肠转位术(BPD-DS)通常适用于体重指数(BMI)>50kg/m²的患者。我们旨在评估采用150cm共同通道(CC)、150cm Roux袢和60F扩张器的BPD-DS在病态肥胖(BMI 35kg/m²且<50kg/m²)患者中的安全性。

方法

对2016年至2019年在单一机构接受BPD-DS的BMI<50mg/k²的患者进行回顾性研究。使用张力最小的腹腔镜器械测量肠袢长度。用60F扩张器进行袖状胃切除术。在适当情况下,使用配对t检验、卡方分析或重复测量方差分析比较变量。

结果

4名患者接受了BPD-DS。CC长度和Roux袢长度分别为158±20cm和154±18cm。术前BMI为44.9±2.3kg/m²,随访时间为2.7±1.4年。1名患者因出血需要再次手术,死于多器官功能衰竭和延迟性袖状胃漏。有1例(2.2%)因吻合口局限性漏再次入院,30天内有2次急诊就诊(4.5%)。没有出现边缘性溃疡、肠袢长度修正或肠内营养需求。超重减轻百分比为67.2±19.7%。88.9%(N=8)、86.6%(N=13)和55.5%(N=5)的患者分别实现了2型糖尿病、高血压和高脂血症的缓解或改善。40%(N=4)的患者胃食管反流病(GERD)得到缓解,11.4%(N=5)出现新发GERD。32%(N=14)的患者维生素D缺乏,25%(N=11)出现锌缺乏。

结论

对于BMI<50kg/m²、采用150cm CC、150cm Roux袢和60F扩张器袖状胃切除术的患者,可考虑行BPD-DS。体重持续减轻,未出现蛋白质热量营养不良,但维生素D和锌缺乏仍然是一个挑战。需要仔细选择患者并对风险和益处进行适当的咨询。

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