Kubo Miwa, Gima Minori, Baba Kohei, Nakai Megumi, Harada Kenichi, Suenaga Midori, Matsunaga Yoichi, Kato Eishin, Hosoda Shinya, Fukuyama Yoshiyasu
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima 770-8514, Japan.
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima 770-8514, Japan.
Bioorg Med Chem Lett. 2015 Apr 1;25(7):1586-91. doi: 10.1016/j.bmcl.2015.02.005. Epub 2015 Feb 12.
Two new curcuminoids 1 and 2, and a new phenylbutenoid dimer 3, were isolated from Bangle (Zingiber purpureum). Their structures were determined on the basis of comprehensive spectroscopic data and their biogenetic pathway. Compounds 1 and 2 are the first example of curcumin coupled with phenylbutenoid. Compounds 1 and 2 promoted neurite outgrowth of NGF-mediated PC12 cells at concentrations ranging from 1 to 10 μM. In addition, compound 1 was found to accelerate the prevention of Aβ42 aggregation.
从紫姜（Zingiber purpureum）中分离出两种新的姜黄素类化合物1和2，以及一种新的苯基丁烯类二聚体3。基于综合光谱数据及其生源合成途径确定了它们的结构。化合物1和2是姜黄素与苯基丁烯类结合的首个实例。化合物1和2在1至10μM的浓度范围内促进了NGF介导的PC12细胞的神经突生长。此外，发现化合物1可加速对Aβ42聚集的抑制。
