Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Faculty of Health Sciences, University College of MAIWP International, Kuala Lumpur 68100, Malaysia.
Nutrients. 2023 May 30;15(11):2564. doi: 10.3390/nu15112564.
The Zingiberaceae family possess various phenolic compounds that have significant systemic bioactivities in the brain, including in age-related neurodegenerative diseases. Neurotrophins are growth factors that protect neurons from oxidative stress, and dysregulation of the neurotrophic system may result in neurocognitive disease. Phenolic compounds from the Zingiberaceae family have been used in traditional and complementary medicine (TCM) to improve cognitive functions. These compounds may affect the expression of neurotrophic agents, but their underlying molecular mechanisms require further investigation. Therefore, the goal of this review is to determine the expression and functional roles of phenolic compounds from the Zingiberaceae family in brain disorders and age-related neurodegenerative disorders. While previous studies have proposed various mechanisms for the neuroprotective activity of these compounds, their precise mechanism of action remains complex and poorly understood. Despite some promising findings, there are still shortcomings in the therapeutic use of these herbs, and current interventions involving the Zingiberaceae family appear to be clinically insufficient. This article aims to summarize recent discoveries of phenolic compounds from several Zingiberaceae family members and their use as neuroprotectants and provide the first review of evidence-linked neuroprotective activity of bioactive ingredients from prominent members of the Zingiberaceae family.
姜科具有多种酚类化合物，这些化合物在大脑中有重要的全身生物活性，包括与年龄相关的神经退行性疾病。神经营养因子是保护神经元免受氧化应激的生长因子，神经营养系统的失调可能导致神经认知疾病。姜科的酚类化合物已被用于传统和补充医学（TCM）以改善认知功能。这些化合物可能会影响神经营养因子的表达，但它们的潜在分子机制需要进一步研究。因此，本综述的目的是确定姜科酚类化合物在脑疾病和与年龄相关的神经退行性疾病中的表达和功能作用。虽然以前的研究提出了这些化合物的神经保护活性的各种机制，但它们的确切作用机制仍然很复杂，知之甚少。尽管有一些有希望的发现，但这些草药在治疗中的应用仍然存在缺陷，目前涉及姜科的干预措施似乎在临床上还不够。本文旨在总结几种姜科成员的酚类化合物的最新发现及其作为神经保护剂的用途，并首次综述姜科主要成员的生物活性成分的证据相关的神经保护活性。
