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阿根廷北部山羊因摄入粉红牵牛(圆叶牵牛)疑似患天然溶酶体贮积病。

Suspected natural lysosomal storage disease from ingestion of pink morning glory (Ipomoea carnea) in goats in northern Argentina.

作者信息

Ríos Elvio E, Cholich Luciana A, Chileski Gabriela, García Enrique N, Lértora Javier, Gimeno Eduardo J, Guidi María G, Mussart Norma, Teibler Gladys P

机构信息

Faculty of Veterinary Sciences, National University of Northeast (UNNE), Corrientes, Argentina.

出版信息

J Vet Med Sci. 2015 Jul;77(7):847-50. doi: 10.1292/jvms.14-0317. Epub 2015 Mar 2.

DOI:10.1292/jvms.14-0317
PMID:25728544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4527508/
Abstract

This study describes an occurrence of pink morning glory (Ipomoea carnea) intoxication in goats in northern Argentina. The clinical signs displayed by the affected animals were ataxia, lethargy, emaciation, hypertonia of the neck muscles, spastic paresis in the hind legs, abnormal postural reactions and death. The clinico-pathologic examination revealed that the affected animals were anemic and their serum level of aspartate aminotransferase was significantly increased. Cytoplasmic vacuolation in the Purkinje cells and pancreatic acinar cells was observed by histological examination. The neuronal lectin binding pattern showed a strong positive reaction to WGA (Triticum vulgaris), sWGA (succinylated T. vulgaris) and LCA (Lens culinaris). Although I. carnea is common in tropical regions, this is the first report of spontaneous poisoning in goats in Argentina.

摘要

本研究描述了阿根廷北部山羊发生的粉红牵牛(Ipomoea carnea)中毒事件。患病动物表现出的临床症状有共济失调、嗜睡、消瘦、颈部肌肉张力亢进、后腿痉挛性轻瘫、异常姿势反应以及死亡。临床病理检查显示,患病动物贫血,其血清天冬氨酸转氨酶水平显著升高。组织学检查观察到浦肯野细胞和胰腺腺泡细胞出现细胞质空泡化。神经元凝集素结合模式显示对小麦胚芽凝集素(WGA)、琥珀酰化小麦胚芽凝集素(sWGA)和菜豆凝集素(LCA)有强烈阳性反应。尽管粉红牵牛在热带地区很常见,但这是阿根廷山羊自发性中毒的首例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f2/4527508/ea1c5692d750/jvms-77-847-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f2/4527508/b4dae3528c69/jvms-77-847-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f2/4527508/a0212faebd09/jvms-77-847-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f2/4527508/ea1c5692d750/jvms-77-847-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f2/4527508/b4dae3528c69/jvms-77-847-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f2/4527508/a0212faebd09/jvms-77-847-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f2/4527508/ea1c5692d750/jvms-77-847-g003.jpg

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本文引用的文献

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Cerebellar ataxia suspected to be caused by Oxytropis glabra poisoning in western Mongolian goats.怀疑由蒙古西部山羊光棘豆中毒引起的小脑性共济失调。
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The guinea pig as an animal model for Ipomoea carnea induced alpha-mannosidosis.
豚鼠作为洋金花诱导的α-甘露糖苷贮积症的动物模型。
Toxicon. 2009 Sep 1;54(3):276-82. doi: 10.1016/j.toxicon.2009.04.012. Epub 2009 Apr 22.
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Spontaneous and experimental glycoprotein storage disease of goats induced by Ipomoea carnea subsp fistulosa (Convolvulaceae).由裂叶牵牛(旋花科)诱发的山羊自发性和实验性糖蛋白贮积病。
Vet Pathol. 2007 Mar;44(2):170-84. doi: 10.1354/vp.44-2-170.
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Lysosomal storage disease caused by Sida carpinifolia poisoning in goats.山羊中由刺蒴麻中毒引起的溶酶体贮积病。
Vet Pathol. 2000 Mar;37(2):153-9. doi: 10.1354/vp.37-2-153.
7
A lysosomal storage disease induced by Ipomoea carnea in goats in Mozambique.莫桑比克山羊中由肉垂麦牵牛引发的一种溶酶体贮积病。
J Vet Diagn Invest. 1999 May;11(3):266-73. doi: 10.1177/104063879901100310.
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Lysosomal storage diseases of animals: an essay in comparative pathology.
Vet Pathol. 1997 Nov;34(6):527-48. doi: 10.1177/030098589703400601.
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Identification of glycoprotein storage diseases by lectins: a new diagnostic method.通过凝集素鉴定糖蛋白贮积病:一种新的诊断方法。
J Histochem Cytochem. 1984 Dec;32(12):1280-4. doi: 10.1177/32.12.6501863.