Micheloud Juan Francisco, Marin Raúl, Colque-Caro Luis Adrián, Martínez Olga Gladys, Gardner Dale, Gimeno Eduardo Juan
Grupo de Trabajo de Patología, Epidemiología e Investigación Diagnóstica, Área de Sanidad Animal-IIACS/INTA, Salta, Argentina; Facultad de Ciencias Veterinarias y Agrarias-UCASAL, Salta, Argentina.
Cátedra de Producción Bovina, Universidad Nacional de Jujuy, Jujuy, Argentina.
Toxicon. 2017 Mar 15;128:1-4. doi: 10.1016/j.toxicon.2016.12.011. Epub 2017 Jan 16.
There are numerous poisonous plants that can induce intralysosomal accumulation of glycoproteins and neurologic syndromes. Here we describe for the first time, a disease caused by ingesting Sida rodrigoi Monteiro in goats in North-western Argentina. The animals showed weight loss, indifference to the environment, unsteady gait and ataxia. Histopathologic studies showed vacuolization in cells of various organs, mainly in the CNS. The material deposited in the cells was positive for LCA (Lens culinaris agglutinin), WGA (Triticum vulgaris agglutinin), sWGA (succinyl-Triticum vulgaris agglutinin) and Con-A (Concanavalia ensiformis agglutinin) lectins. Finally, toxic levels of swansonine were identified in the plant. The present investigation allowed to recognize S. rodrigoi Monteiro poisoning as a plant induced α-mannosidosis.
有许多有毒植物可导致溶酶体内糖蛋白积累和神经综合征。在此，我们首次描述了阿根廷西北部山羊因摄入罗德瑞格 sida（Sida rodrigoi Monteiro）而引发的一种疾病。这些动物表现出体重减轻、对环境冷漠、步态不稳和共济失调。组织病理学研究显示各器官细胞出现空泡化，主要发生在中枢神经系统。细胞内沉积的物质对扁豆凝集素（LCA）、小麦胚芽凝集素（WGA）、琥珀酰小麦胚芽凝集素（sWGA）和刀豆球蛋白A（Con-A）呈阳性。最后，在该植物中鉴定出了毒马桑毒素的毒性水平。本研究使我们认识到罗德瑞格 sida中毒是一种植物诱导的α-甘露糖苷贮积症。
