Saima Rasheed Saima Rasheed, Naz Shaista, Naheed Suad, Choudhary Muhammad Iqbal
Department of Chemistry, Federal Urdu University of Arts, Science & Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan.
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
Pak J Pharm Sci. 2015 Mar;28(2):521-3.
Anti-glycation and α-glucosidase inhibition activities of microbial transformed compounds of dydrogesterone (1); 20R-hydroxy-9β,10αa-pregna-4,6-diene-3-one (2), 17β-hydroxy-9β,10α-androsta-4,6-diene-3-one (3) and 9β,10α-androsta-4,6-diene-3,17-dione (4) were evaluated. Compounds 1 and 4 showed potent α-glucosidase inhibitory activities, while 2 and 3 were found to be weak inhibitors, whereas anti-glycation activities of 1-4 were not observed.
对醋酸甲羟孕酮（1）、20R-羟基-9β,10αa-孕甾-4,6-二烯-3-酮（2）、17β-羟基-9β,10α-雄甾-4,6-二烯-3-酮（3）和9β,10α-雄甾-4,6-二烯-3,17-二酮（4）的微生物转化产物的抗糖化和α-葡萄糖苷酶抑制活性进行了评估。化合物1和4表现出较强的α-葡萄糖苷酶抑制活性，而2和3被发现是弱抑制剂，而未观察到1-4的抗糖化活性。
