Jeong Gyeong Han, Kim Tae Hoon
Department of Food Science and Biotechnology, Daegu University.
Chem Pharm Bull (Tokyo). 2017;65(7):678-682. doi: 10.1248/cpb.c17-00190.
Rutin, a major flavonoid glycoside found in many higher plants, was exposed at 25 kGy of γ-ray and produced three new hydroxymethylated products 2-4 in the C-ring by γ-irradiation. Structures of the new compounds, including absolute configurations, were elucidated based on spectroscopic interpretation (NMR, UV, [α], MS, and circular dichroism (CD)). The new unusual rutin derivatives 2 and 3 exhibited significantly enhanced inhibitory effects against α-glucosidase with IC values of 23.1±1.2 and 11.2±0.7 µM, respectively, when compared to the parent rutin.
芦丁是一种在许多高等植物中发现的主要黄酮糖苷，经25千戈瑞的γ射线辐照后，通过γ辐射在C环上产生了三种新的羟甲基化产物2 - 4。基于光谱解释（核磁共振、紫外、旋光度、质谱和圆二色性（CD））阐明了新化合物的结构，包括绝对构型。与母体芦丁相比，新的异常芦丁衍生物2和3对α - 葡萄糖苷酶表现出显著增强的抑制作用，其IC值分别为23.1±1.2和11.2±0.7微摩尔。
