Otsubo Dai, Sawa Hidehiro, Fukuoka Eiji, Murata Kouichi, Mii Yasuhiko, Oka Shigeteru, Iwatani Yoshiteru, Kuroda Daisuke
Dept. of Surgery, Kita-Harima Medical Center.
Gan To Kagaku Ryoho. 2014 Nov;41(12):2402-4.
We report a case of a large gastric gastrointestinal stromal tumor (GIST), which became resectable and achieved pathological complete response after neoadjuvant chemotherapy with imatinib mesylate. A 59-year-old man presented with left hypochondrial pain. Abdominal computed tomography (CT) revealed gastric GIST invading the spleen and the diaphragm. Administration of imatinib mesylate was initiated as neoadjuvant chemotherapy. Six months after neoadjuvant chemotherapy with imatinib mesylate, abdominal CT revealed a reduction in tumor size. We judged the tumor resectable and performed partial gastrectomy and splenectomy. Histologically, number of myofibroblasts increased, but no viable tumor cells were observed. Pathological complete response was obtained.
我们报告一例大型胃胃肠道间质瘤（GIST）病例，该病例在接受甲磺酸伊马替尼新辅助化疗后变得可切除并实现了病理完全缓解。一名59岁男性因左季肋部疼痛就诊。腹部计算机断层扫描（CT）显示胃GIST侵犯脾脏和膈肌。开始给予甲磺酸伊马替尼作为新辅助化疗。在接受甲磺酸伊马替尼新辅助化疗6个月后，腹部CT显示肿瘤大小缩小。我们判断肿瘤可切除，遂行胃部分切除术和脾切除术。组织学检查显示肌成纤维细胞数量增加，但未观察到存活的肿瘤细胞。获得了病理完全缓解。
