Pierson W E, Furukawa C T, Shapiro G G, Altman L C, Bierman C W
Department of Pediatrics, University of Washington, Seattle.
Ann Allergy. 1989 Nov;63(5):461-4.
Terfenadine, in doses of 60, 120, and 180 mg, provided significant bronchodilation for up to four hours after administration. In addition, when the same doses were given four hours prior to exercise, the drug demonstrated significant blockade of exercise-induced bronchospasm at two and five minutes postexercise. These effects on exercise-induced bronchospasm followed a dose-response curve; 180 mg had the most significant effect. All dosing levels, however, produced both bronchodilation and a significant degree of blockade of exercise-induced bronchospasm. No patients were bothered by adverse effects during this single-dose study. Eight of the 11 subjects who completed the study also noted some improvement in their nasal congestion during the testing period when they were on the active drug.
特非那定剂量为60毫克、120毫克和180毫克时，给药后长达四小时可产生显著的支气管扩张作用。此外，在运动前四小时给予相同剂量时，该药物在运动后两分钟和五分钟时对运动诱发的支气管痉挛有显著的阻断作用。这些对运动诱发支气管痉挛的作用呈剂量反应曲线；180毫克的效果最显著。然而，所有给药水平均产生了支气管扩张作用以及对运动诱发支气管痉挛的显著阻断作用。在这项单剂量研究中，没有患者受到不良反应的困扰。完成研究的11名受试者中有8人还指出，在服用活性药物的测试期间，他们的鼻塞也有了一定改善。
