Pollock J, Kiechel F, Cooper D, Weinberger M
Pediatrics. 1977 Dec;60(6):840-4.
Exercise-induced bronchospasm was induced by treadmill running in 12 children on two days preceding either inhaled cromolyn sodium (Intal) or oral theophylline (Slo-Phyllin tablets), 7.5 mg/kg, administered in a double-blind manner. A second exercise period identical to the first followed two hours later; the medication administration had been timed so that the second exercise stress followed two hours after theophylline administration and 15 minutes following cromolyn administration. The patients subsequently were exercised twice more at two-hour intervals on both days. Blood was drawn from serum theophylline measurement immediately after each of the exercise periods. There was little demonstrable exercise-induced bronchospasm resulting from the first postmedication exercise period following theophylline administration. The two subsequent exercise periods were associated with some return of postexercise bronchospasm. The degree of inhibition of exercise-induced bronchospasm correlated with serum theophylline levels that averaged 16, 13, and 10 microgram/ml at two, four and six hours after the theophylline dose (mean Spearman rank correlation coefficient = .71, P less than .01). The effect of cromolyn in suppression exercise-induced bronchospasm that matched or excelled that seen with theophylline.
在12名儿童中，于吸入色甘酸钠（因他利）或口服氨茶碱（舒弗美片），剂量为7.5毫克/千克，采用双盲方式给药的前两天，通过跑步机跑步诱发运动诱发性支气管痉挛。两小时后进行与第一次相同的第二个运动时段；药物给药时间安排为，第二次运动应激在氨茶碱给药两小时后且在色甘酸钠给药15分钟后进行。随后患者在这两天以两小时的间隔又进行了两次运动。在每个运动时段结束后立即抽取血液用于测定血清氨茶碱水平。氨茶碱给药后的第一个用药后运动时段几乎没有明显的运动诱发性支气管痉挛。随后的两个运动时段出现了运动后支气管痉挛的某种程度的复发。运动诱发性支气管痉挛的抑制程度与氨茶碱给药后两小时、四小时和六小时血清氨茶碱水平相关，平均分别为16、13和10微克/毫升（平均斯皮尔曼等级相关系数 = 0.71，P小于0.01）。色甘酸钠在抑制运动诱发性支气管痉挛方面的效果与氨茶碱相当或更优。
