神经艾滋病的HIV-1转基因大鼠模型。
The HIV-1 transgenic rat model of neuroHIV.
作者信息
Vigorito Michael, Connaghan Kaitlyn P, Chang Sulie L
机构信息
Institute of NeuroImmune Pharmacology and Department of Biological Sciences, Seton Hall University, South Orange, NJ, USA.
Institute of NeuroImmune Pharmacology and Department of Biological Sciences, Seton Hall University, South Orange, NJ, USA.
出版信息
Brain Behav Immun. 2015 Aug;48:336-49. doi: 10.1016/j.bbi.2015.02.020. Epub 2015 Feb 27.
Despite the ability of current combination anti-retroviral therapy (cART) to limit the progression of HIV-1 to AIDS, HIV-positive individuals continue to experience neuroHIV in the form of HIV-associated neurological disorders (HAND), which can range from subtle to substantial neurocognitive impairment. NeuroHIV may also influence substance use, abuse, and dependence in HIV-positive individuals. Because of the nature of the virus, variables such as mental health co-morbidities make it difficult to study the interaction between HIV and substance abuse in human populations. Several rodent models have been developed in an attempt to study the transmission and pathogenesis of the HIV-1 virus. The HIV-1 transgenic (HIV-1Tg) rat is a reliable model of neuroHIV because it mimics the condition of HIV-infected patients on cART. Research using this model supports the hypothesis that the presence of HIV-1 viral proteins in the central nervous system increases the sensitivity and susceptibility of HIV-positive individuals to substance abuse.
尽管目前的联合抗逆转录病毒疗法（cART）有能力限制HIV-1发展为艾滋病，但HIV阳性个体仍会以与HIV相关的神经障碍（HAND）的形式经历神经HIV，其范围可从轻微到严重的神经认知障碍。神经HIV也可能影响HIV阳性个体的物质使用、滥用和依赖。由于病毒的特性，诸如心理健康共病等变量使得在人群中研究HIV与物质滥用之间的相互作用变得困难。为了研究HIV-1病毒的传播和发病机制，已经开发了几种啮齿动物模型。HIV-1转基因（HIV-1Tg）大鼠是神经HIV的可靠模型，因为它模拟了接受cART治疗的HIV感染患者的情况。使用该模型的研究支持这样的假设，即中枢神经系统中HIV-1病毒蛋白的存在会增加HIV阳性个体对物质滥用的敏感性和易感性。
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