Persson J, Magnusson P H
Department of Internal Medicine, University Hospital of Lund, Sweden.
Alcohol. 1989 Sep-Oct;6(5):403-8. doi: 10.1016/0741-8329(89)90011-6.
From a population of 2,114 patients attending somatic outpatient clinics, 78 patients were selected who had either an excessive consumption of alcohol according to questionnaires or a raised gamma glutamyltransferase (GGT) value (above 0.6 mu kat/l) due to alcohol. They had not undergone treatment for problem drinking previously, and had no serious alcohol dependence. They were thereby classified as excessive consumers of alcohol, and randomly allocated to an intervention (n = 36) or to a control group (n = 42). Those in the intervention group were followed up by a nurse once a month and by a doctor every third month for a total of 12 months. Laboratory tests were taken monthly. Consumption of alcohol, GGT and triglyceride levels, and sickness allowance days were decreased in the intervention group compared to the time before intervention. In contrast, the number of sickness allowance days in the control group increased. There was also a tendency towards a positive effect of intervention on the number of consultations made with a statistically not significant decrease of consultations after intervention. The study thus indicates that an early and relatively simple intervention programme for problem drinkers may be effective and can be carried out at a low cost and with a positive response from the patients.
从2114名到躯体门诊就诊的患者中，选取了78名患者，这些患者要么根据问卷调查显示饮酒过量，要么因饮酒导致γ-谷氨酰转移酶（GGT）值升高（高于0.6微摩尔/升）。他们之前未曾接受过针对饮酒问题的治疗，也没有严重的酒精依赖。因此，他们被归类为饮酒过量者，并被随机分配到干预组（n = 36）或对照组（n = 42）。干预组的患者由一名护士每月随访一次，由一名医生每三个月随访一次，共随访12个月。每月进行实验室检查。与干预前相比，干预组的酒精消费量、GGT和甘油三酯水平以及病假天数均有所下降。相比之下，对照组的病假天数增加。干预对就诊次数也有积极影响的趋势，干预后就诊次数虽有下降，但在统计学上不显著。因此，该研究表明，针对问题饮酒者的早期且相对简单的干预方案可能是有效的，并且可以低成本实施，患者反应良好。
