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同室住院的早产儿肠道细菌很少共享，无论是否发生坏死性小肠结肠炎。

Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development.

作者信息

Raveh-Sadka Tali, Thomas Brian C, Singh Andrea, Firek Brian, Brooks Brandon, Castelle Cindy J, Sharon Itai, Baker Robyn, Good Misty, Morowitz Michael J, Banfield Jillian F

机构信息

Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, United States.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States.

出版信息

Elife. 2015 Mar 3;4:e05477. doi: 10.7554/eLife.05477.

DOI:10.7554/eLife.05477
PMID:25735037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4384745/
Abstract

Premature infants are highly vulnerable to aberrant gastrointestinal tract colonization, a process that may lead to diseases like necrotizing enterocolitis. Thus, spread of potential pathogens among hospitalized infants is of great concern. Here, we reconstructed hundreds of high-quality genomes of microorganisms that colonized co-hospitalized premature infants, assessed their metabolic potential, and tracked them over time to evaluate bacterial strain dispersal among infants. We compared microbial communities in infants who did and did not develop necrotizing enterocolitis. Surprisingly, while potentially pathogenic bacteria of the same species colonized many infants, our genome-resolved analysis revealed that strains colonizing each baby were typically distinct. In particular, no strain was common to all infants who developed necrotizing enterocolitis. The paucity of shared gut colonizers suggests the existence of significant barriers to the spread of bacteria among infants. Importantly, we demonstrate that strain-resolved comprehensive community analysis can be accomplished on potentially medically relevant time scales.

摘要

早产儿极易受到胃肠道异常定植的影响，这一过程可能导致诸如坏死性小肠结肠炎等疾病。因此，潜在病原体在住院婴儿之间的传播备受关注。在此，我们重建了数百个定植于同室住院早产儿的微生物高质量基因组，评估了它们的代谢潜能，并随时间对其进行追踪，以评估细菌菌株在婴儿之间的传播情况。我们比较了发生和未发生坏死性小肠结肠炎的婴儿的微生物群落。令人惊讶的是，虽然同一物种的潜在致病细菌定植于许多婴儿，但我们基于基因组解析的分析表明，定植于每个婴儿的菌株通常是不同的。特别是，没有一个菌株在所有发生坏死性小肠结肠炎的婴儿中都存在。共享肠道定植菌的匮乏表明婴儿之间细菌传播存在重大障碍。重要的是，我们证明了可以在潜在与医学相关的时间尺度上完成基于菌株解析的综合群落分析。

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2
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J Proteome Res. 2015 Jan 2;14(1):491-502. doi: 10.1021/pr500759e. Epub 2014 Oct 28.
3
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4
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6
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