Wang Yu-Chieh, Lin Victor, Loring Jeanne F, Peterson Suzanne E
The University of North Texas Health Science Center, Department of Pharmaceutical Sciences , 3500 Camp Bowie Boulevard, RES-314G, Fort Worth, TX 76107 , USA +1 817 735 2944 ; +1 817 735 2603 ;
Expert Opin Biol Ther. 2015 May;15(5):679-87. doi: 10.1517/14712598.2015.1021329. Epub 2015 Mar 3.
Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cellular activities including pluripotency in hPSCs. The primary focus of this review article is to highlight recent advances in stem cell research from a glycobiological perspective. We also discuss how our understanding of glycans and glycosylation may help overcome barriers hindering the clinical application of hPSC-derived cells.
A literature survey using NCBI-PubMed and Google Scholar was performed in 2014.
Regenerative medicine hopes to provide novel strategies to combat human disease and tissue injury that currently lack effective therapies. Although progress in this field is accelerating, many critical issues remain to be addressed in order for cell-based therapy to become a practical and safe treatment option. Emerging evidence suggests that protein glycosylation may significantly influence the regulation of cellular pluripotency, and that the exploitation of protein glycosylation in hPSCs and their differentiated derivatives may lead to transformative and translational discoveries for regenerative medicine. In addition, hPSCs represent a novel research platform for investigating glycosylation-related disease.
人类多能干细胞（hPSCs）为再生医学的未来带来了希望。聚糖所具有的结构和生化多样性使其成为一种独特的大分子修饰类型，参与调控大量生化事件和细胞活动，包括hPSCs的多能性。本文综述的主要重点是从糖生物学角度突出干细胞研究的最新进展。我们还将讨论我们对聚糖和糖基化的理解如何有助于克服阻碍hPSC衍生细胞临床应用的障碍。
2014年利用NCBI - PubMed和谷歌学术进行了文献调查。
再生医学希望提供新策略来对抗目前缺乏有效治疗方法的人类疾病和组织损伤。尽管该领域进展加速，但为使基于细胞的疗法成为切实可行且安全的治疗选择，仍有许多关键问题有待解决。新出现的证据表明，蛋白质糖基化可能显著影响细胞多能性的调控，并且在hPSCs及其分化衍生物中利用蛋白质糖基化可能会为再生医学带来变革性和转化性的发现。此外，hPSCs代表了一个用于研究糖基化相关疾病的新型研究平台。
