Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania. McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Cancer Res. 2015 Apr 1;75(7):1161-8. doi: 10.1158/0008-5472.CAN-14-2744. Epub 2015 Mar 3.
Obesity is a well recognized risk factor for several types of cancers, many of which occur solely or disproportionately in women. Adipose tissue is a rich source of adipose-derived stem cells (ASC), which have received attention for their role in cancer behavior. The purpose of this systematic review is to present the existing literature on the role of ASCs in the growth, development, progression, and metastasis of cancer, with an emphasis on malignancies that primarily affect women. To accomplish this goal, the bibliographic database PubMed was systematically searched for articles published between 2001 and 2014 that address ASCs' relationship to human cancer. Thirty-seven articles on ASCs' role in human cancer were reviewed. Literature suggests that ASCs exhibit cancer-promoting properties, influence/are influenced by the tumor microenvironment, promote angiogenesis, and may be associated with pathogenic processes through a variety of mechanisms, such as playing a role in hypoxic tumor microenvironment. ASCs appear to be important contributors to tumor behavior, but research in areas specific to women's cancers, specifically endometrial cancer, is scarce. Also, because obesity continues to be a major health concern, it is important to continue research in this area to improve understanding of the impact adiposity has on cancer incidence.
肥胖是多种癌症的一个公认的危险因素，其中许多癌症仅在女性中发生或在女性中更为多发。脂肪组织是脂肪来源干细胞（ASC）的丰富来源，其在癌症行为中的作用受到关注。本系统评价的目的是介绍现有的关于 ASC 在癌症生长、发展、进展和转移中的作用的文献，重点关注主要影响女性的恶性肿瘤。为了实现这一目标，系统地检索了 2001 年至 2014 年间发表的涉及 ASC 与人类癌症关系的文献数据库 PubMed。对 37 篇关于 ASC 在人类癌症中作用的文献进行了综述。文献表明，ASC 具有促进癌症的特性，影响/受肿瘤微环境的影响，促进血管生成，并可能通过多种机制与发病过程相关，例如在缺氧肿瘤微环境中发挥作用。ASC 似乎是肿瘤行为的重要贡献者，但针对女性癌症（特别是子宫内膜癌）的特定领域的研究很少。此外，由于肥胖仍然是一个主要的健康问题，因此继续在这一领域进行研究对于提高对肥胖对癌症发病率的影响的理解非常重要。
