Bedir Recep, Sehitoglu Ibrahim, Yurdakul Cüneyt, Saygin Ismail, Üstüner Pelin, Dilek Nursel
Assistant Professor, Department of Pathology, Recep Tayyip Erdogan University, Medical Faculty , Rize, Turkey .
Medical Doctor, Department of Pathology, Recep Tayyip Erdogan University, Medical Faculty , Rize, Turkey .
J Clin Diagn Res. 2015 Jan;9(1):EC01-4. doi: 10.7860/JCDR/2015/10915.5414. Epub 2015 Jan 1.
Basal cell carcinoma (BCC) is the most common skin neoplasm reported in human. On the other hand, trichoepithelioma (TE) is a rare, benign tumour of skin adnexa. The differentiation of BCC and TE may be difficult since their morphological findings are similar. In a few studies, it has been determined that undifferentiated basaloid cells are highly positively stained with cytokeratin 19.
The aim of this study was the comparison of cytokeratin 19 expression in cases of BCC and TE.
Sections of skin tissues of 17 TE, 25 BCC and 12 non-neoplastic cases were used for cytokeratin 19 (CK19) immunohistochemical staining.
Staining with CK19 of the BCC cases gave 15(60%) diffuse, 7 (28%) focal and 3 (12%) negative staining. On the other hand, among TE cases, 2 (12%) gave diffuse, 5 (29%) focal and 10 (59%) negative staining with CK19. In the non-neoplastic skin tissue samples, while positive staining with cytokeratin 19 in the outer root sheath of hair follicles and sweat glands were observed, there was no staining in basal layers.
CK19 expression may be helpful in the differential diagnosis of BCC and TE especially in small skin biopsy samples in which morphologic differentiation is difficult.
基底细胞癌（BCC）是人类报告中最常见的皮肤肿瘤。另一方面，毛发上皮瘤（TE）是一种罕见的皮肤附属器良性肿瘤。由于BCC和TE的形态学表现相似，它们的鉴别可能具有挑战性。在一些研究中，已确定未分化的基底样细胞细胞角蛋白19高度阳性染色。
本研究的目的是比较BCC和TE病例中细胞角蛋白19的表达。
对17例TE、25例BCC和12例非肿瘤病例的皮肤组织切片进行细胞角蛋白19（CK19）免疫组化染色。
BCC病例的CK19染色显示15例（60%）弥漫性、7例（28%）局灶性和3例（12%）阴性染色。另一方面，在TE病例中，2例（12%）为弥漫性、5例（29%）为局灶性、10例（59%）为CK19阴性染色。在非肿瘤性皮肤组织样本中，虽然在毛囊外根鞘和汗腺中观察到细胞角蛋白19阳性染色，但基底层无染色。
CK19表达可能有助于BCC和TE的鉴别诊断，特别是在形态学鉴别困难的小皮肤活检样本中。
