Pinkston Christina M, Baumgartner Richard N, Connor Avonne E, Boone Stephanie D, Baumgartner Kathy B
Department of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.
Department of Epidemiology and Population Health, School of Public Health and Information Sciences, James Graham Brown Cancer Center, University of Louisville, 485 E. Gray St., Louisville, 40202, KY, USA.
J Cancer Surviv. 2015 Dec;9(4):650-9. doi: 10.1007/s11764-015-0441-3. Epub 2015 Mar 5.
We investigated the association of physical activity with survival for 601 Hispanic women and 682 non-Hispanic white women who participated in the population-based breast cancer case-control New Mexico Women's Health Study.
We identified 240 deaths among cases diagnosed with a first primary invasive breast cancer between 1992 and 1994, and 88 deaths among controls. Follow-up extended through 2012 for cases and 2008 for controls. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression.
Higher levels of total physical activity were inversely associated with all-cause mortality among Hispanic cases (Quartile (Q)4: HR = 0.55, 95% CI 0.31-0.99). A non-significant trend was observed for recreational activity in Hispanic cases also (Q4: HR = 0.50, 95% CI 0.23-1.09, p for trend = 0.08). No significant associations were noted for non-Hispanic white cases or for controls.
The results suggest that increasing physical activity may be protective against mortality in Hispanic women with breast cancer, despite reporting lower levels of recreational activity than non-Hispanic white women or Hispanic controls.
Public health programs in Hispanic communities should promote physical activity in women as a means of decreasing breast cancer risk and improving survival.
我们调查了参与基于人群的乳腺癌病例对照研究——新墨西哥州妇女健康研究的601名西班牙裔女性和682名非西班牙裔白人女性的身体活动与生存率之间的关联。
我们确定了1992年至1994年间被诊断为原发性浸润性乳腺癌的病例中有240例死亡，对照中有88例死亡。病例的随访持续到2012年，对照的随访持续到2008年。使用Cox比例风险回归估计多变量风险比（HR）和95%置信区间（CI）。
在西班牙裔病例中，较高水平的总体身体活动与全因死亡率呈负相关（四分位数（Q）4：HR = 0.55，95% CI 0.31 - 0.99）。在西班牙裔病例的休闲活动中也观察到一种不显著的趋势（Q4：HR = 0.50，95% CI 0.23 - 1.09，趋势p值 = 0.08）。在非西班牙裔白人病例或对照中未发现显著关联。
结果表明，增加身体活动可能对患有乳腺癌的西班牙裔女性的死亡率具有保护作用，尽管她们报告的休闲活动水平低于非西班牙裔白人女性或西班牙裔对照。
西班牙裔社区的公共卫生项目应促进女性进行身体活动，以此作为降低乳腺癌风险和提高生存率的一种手段。
