Ratcliff A, Indalo A A, Bradshaw E G, Rye R M
Department of Anaesthetics, University of Manchester, Hope Hospital, Salford.
Anaesthesia. 1989 Oct;44(10):812-5. doi: 10.1111/j.1365-2044.1989.tb09097.x.
Fourteen patients received oral premedication of temazepam in soft gelatin capsules before minor surgery. The plasma concentrations of temazepam and its sedative, anxiolytic and amnesic effects were measured for 24 hours. Absorption was rapid and peak concentrations occurred 49 minutes after administration. Clinical effects were evident at 30 minutes and persisted for about 4 hours. The decline in plasma concentration was biexponential with a distribution half-life of 1.24 hours. The end of the distribution phase coincided approximately with the termination of its clinical effects. A relationship between plasma concentration and effect was observed; concentrations above 300 ng/ml produced measurable changes in tests of mental function. Patients had recovered fully from the effects of temazepam after 24 hours. This dose of temazepam is reliable and effective as premedication before surgery.
14名患者在接受小手术前口服了软胶囊剂型的替马西泮进行术前用药。对替马西泮的血浆浓度及其镇静、抗焦虑和失忆作用进行了24小时的测定。吸收迅速，给药后49分钟出现峰值浓度。30分钟时临床效果明显，并持续约4小时。血浆浓度下降呈双指数形式，分布半衰期为1.24小时。分布阶段结束大致与临床效果终止时间相符。观察到血浆浓度与效果之间存在关系；浓度高于300 ng/ml时，心理功能测试出现可测量的变化。24小时后患者已从替马西泮的作用中完全恢复。这种剂量的替马西泮作为手术前的术前用药可靠且有效。
