Higashi Yukihito
Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University; Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.
Int Heart J. 2015;56(2):125-34. doi: 10.1536/ihj.14-385. Epub 2015 Feb 27.
In 1986, endothelial function was measured for the first time in patients with atherosclerotic coronary arteries. Since then, several methods for assessment of endothelial function, such as endothelium-dependent vasodilation induced by intra-arterial infusion of vasoactive agents using coronary angiography, Doppler flow guide wire, mercury-filled Silastic strain-gauge plethysmography, flow-mediated vasodilation, reactive hyperemia-peripheral arterial tonometry, and vascular response using an oscillometric method have been performed in humans. This review focuses on the assessment of endothelial function, including measurement history, methodological issues, and clinical perspectives.
1986年，首次对动脉粥样硬化性冠状动脉疾病患者的内皮功能进行了测量。从那时起，已在人体中采用了多种评估内皮功能的方法，如使用冠状动脉造影通过动脉内注入血管活性药物诱导的内皮依赖性血管舒张、多普勒血流导丝、充汞硅橡胶应变片体积描记法、血流介导的血管舒张、反应性充血-外周动脉张力测量法以及使用示波法的血管反应。本综述重点关注内皮功能的评估，包括测量历史、方法学问题和临床前景。
