Wirshing W C, Freidenberg D L, Cummings J L, Bartzokis G
Brentwood Movement Disorders Laboratory, UCLA School of Medicine.
J Clin Psychopharmacol. 1989 Dec;9(6):407-11.
Twenty-five percent of 80 consecutive patients who met research criteria for persistent tardive dyskinesia (TD) were found to have an energy peak in the parkinsonian tremor band (3-6 Hz) of the frequency spectrum of their machine-measured resting hand movements in addition to the abnormalities consistent with TD (increased energy in the 0.5-3 Hz frequency spectrum). Twelve of these patients were studied again in double-blind fashion 2 hours after receiving a placebo and again 2 hours after a single 4 mg dose of trihexyphenidyl hydrochloride (HCl). Compared with the placebo condition, the trihexyphenidyl HCl markedly diminished the measured energy in the 4 Hz band and had no effect or slightly decreased the energy at all other points on the frequency spectrum. Simultaneous Abnormal Involuntary Movement Scale ratings revealed no change in the dyskinetic movements between the conditions; there was a significant subjective improvement reported by the patients following the trihexyphenidyl HCl administration. These observations indicate that electromechanical devices identify a subpopulation of TD patients who may acutely benefit from anticholinergic treatment.
在连续80例符合持续性迟发性运动障碍（TD）研究标准的患者中，25%的患者除了具有与TD一致的异常（0.5 - 3Hz频谱能量增加）外，还发现在其机器测量的静息手部运动频谱的帕金森震颤频段（3 - 6Hz）存在能量峰值。其中12例患者在接受安慰剂2小时后以及单次服用4mg盐酸苯海索（HCl）2小时后，以双盲方式再次接受研究。与安慰剂状态相比，盐酸苯海索显著降低了4Hz频段测量的能量，对频谱上所有其他点的能量没有影响或略有降低。同时，异常不自主运动量表评分显示不同状态下运动障碍性运动没有变化；患者在服用盐酸苯海索后报告有明显的主观改善。这些观察结果表明，机电设备识别出了一部分可能从抗胆碱能治疗中急性获益的TD患者。
