1至18个月健康儿童的粪便钙卫蛋白浓度
Fecal calprotectin concentrations in healthy children aged 1-18 months.
作者信息
Li Feng, Ma Jingqiu, Geng Shanshan, Wang Junli, Liu Jinrong, Zhang Jie, Sheng Xiaoyang
机构信息
Department of Children and Adolescents Health Care, MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
PLoS One. 2015 Mar 5;10(3):e0119574. doi: 10.1371/journal.pone.0119574. eCollection 2015.
OBJECTIVE
Fecal calprotectin (FC) is an established biomarker of gut inflammation. The aim of this study was to evaluate FC concentrations in healthy children between 1 and 18 months of age.
METHODS
Healthy children aged 1-18 months were enrolled in this study at the Department of Children's Health Care in Shanghai, China. Children's stool samples were collected and analyzed, and FC concentration was determined using a commercially available enzyme-linked immunosorbent assay (ELISA). The children's weights and lengths were measured. Parents were asked to complete a brief questionnaire regarding several clinical and sociodemographic factors.
RESULTS
The FC concentrations were unevenly distributed; the median FC concentration was 174.3 μg/g (range: 6.0-1097.7 μg/g) or 2.241 log10 μg/g (range: 0.775-3.041 log10 μg/g) for all 288 children. The children were divided into several age groups: 1-3 months, 3-6 months, 6-9 months, 9-12 months and 12-18 months. The median FC concentrations for these age groups were 375.2 μg/g (2.574 log10 μg/g), 217.9 μg/g (2.338 log10 μg/g), 127.7 μg/g (2.106 log10 μg/g), 96.1 μg/g (1.983 log10 μg/g) and 104.2 μg/g (2.016 log10 μg/g), respectively. A significant correlation between age and FC concentration was found (r=-0.490, p<0.001). A simple correlation analysis of weight-for-length Z-scores or weight-for-age Z-scores vs. FC concentrations showed that these variables were negatively correlated (Spearman's rho=-0.287, p<0.001; Spearman's rho=-0.243, p<0.001, respectively).
CONCLUSIONS
The FC levels of children aged 1-18 months exhibit a downward trend with increasing age and are greater than the normal levels observed in healthy adults. In healthy children aged <6 months, FC levels are high. In children aged 6-18 months, FC concentrations are relatively low but are still higher than those of children aged >4 years.
目的
粪便钙卫蛋白（FC）是肠道炎症的一种既定生物标志物。本研究的目的是评估1至18个月大健康儿童的FC浓度。
方法
1至18个月大的健康儿童在中国上海儿童保健科纳入本研究。收集并分析儿童粪便样本，使用市售酶联免疫吸附测定（ELISA）测定FC浓度。测量儿童的体重和身长。要求家长完成一份关于若干临床和社会人口学因素的简短问卷。
结果
FC浓度分布不均；288名儿童的FC浓度中位数为174.3μg/g（范围：6.0 - 1097.7μg/g）或2.241 log10μg/g（范围：0.775 - 3.041 log10μg/g）。儿童被分为几个年龄组：1 - 3个月、3 - 6个月、6 - 9个月、9 - 12个月和12 - 18个月。这些年龄组的FC浓度中位数分别为375.2μg/g（2.574 log10μg/g）、217.9μg/g（2.338 log10μg/g）、127.7μg/g（2.106 log10μg/g）、96.1μg/g（1.983 log10μg/g）和104.2μg/g（2.016 log10μg/g）。发现年龄与FC浓度之间存在显著相关性（r = -0.490，p < 0.001）。身长别体重Z评分或年龄别体重Z评分与FC浓度的简单相关性分析表明，这些变量呈负相关（斯皮尔曼相关系数分别为 -0.287，p < 0.001； -0.243，p < 0.001）。
结论
1至18个月大儿童的FC水平随年龄增长呈下降趋势，且高于健康成年人的正常水平。在6个月以下的健康儿童中，FC水平较高。在6至18个月大的儿童中，FC浓度相对较低，但仍高于4岁以上儿童。
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