Tidjani O, Grunitsky B, Guérin N, Lévy-Bruhl D, Lecam N, Xuereff C, Tatagan K
CHU, Lomé, Togo.
Lancet. 1989 Dec 9;2(8676):1357-60. doi: 10.1016/s0140-6736(89)91967-3.
To examine the value of vaccinating children against measles at age 4-5 months three groups of children in Togo were randomly assigned to receive high-dose Edmonston-Zagreb, high-dose Schwarz, or AIK-C vaccines at that age. Two other groups were vaccinated at age 8-10 months, with either the standard Schwarz vaccine or the same batch of AIK-C as for early immunisation. For the 55% of children who were seronegative before vaccination at age 4-5 months seroconversion rates were 96% with the AIK-C, 94% with the Edmonston-Zagreb, and 50% with the high-dose Schwarz. The immune response rates for children who were seropositive before vaccination were estimated to be around 50% with the high-dose Edmonston-Zagreb and AIK-C strains and 10% with the Schwarz strain. Seroconversion rates for vaccination at 8-10 months were 87% for the AIK-C and 68% for the Schwarz strains. Thus vaccination with the high-dose Edmonston-Zagreb or the AIK-C strain at 4-5 months was as good as vaccination with the AIK-C strain at 8-10 months and better than vaccination with the standard dose Schwarz strain at 8-10 months. These findings require confirmation by further investigations, particularly epidemiological studies, but they already provide evidence that the administration of AIK-C and high-dose Edmonston-Zagreb strains at 4-5 months is at least as effective as vaccination with the standard strains at 8-10 months.
为研究4至5月龄儿童接种麻疹疫苗的价值，多哥的三组儿童被随机分配在该年龄段接种高剂量的埃德蒙斯顿- Zagreb疫苗、高剂量的施瓦茨疫苗或AIK-C疫苗。另外两组在8至10月龄时接种，一组接种标准施瓦茨疫苗，另一组接种与早期免疫相同批次的AIK-C疫苗。对于4至5月龄接种疫苗前血清学阴性的55%的儿童，AIK-C疫苗的血清转化率为96%，埃德蒙斯顿- Zagreb疫苗为94%，高剂量施瓦茨疫苗为50%。接种疫苗前血清学阳性儿童的免疫反应率估计，高剂量埃德蒙斯顿- Zagreb疫苗和AIK-C毒株约为50%，施瓦茨毒株为10%。8至10月龄接种疫苗的血清转化率，AIK-C毒株为87%，施瓦茨毒株为68%。因此，4至5月龄接种高剂量埃德蒙斯顿- Zagreb疫苗或AIK-C毒株与8至10月龄接种AIK-C毒株效果相当，且优于8至10月龄接种标准剂量施瓦茨毒株。这些发现需要进一步研究，特别是流行病学研究来证实，但它们已经提供了证据，表明4至5月龄接种AIK-C和高剂量埃德蒙斯顿- Zagreb毒株至少与8至10月龄接种标准毒株一样有效。
