Saki Forough, Dabbaghmanesh Mohammad Hossein, Ghaemi Seyede Zahra, Forouhari Sedighe, Ranjbar Omrani Gholamhossein, Bakhshayeshkaram Marzieh
Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Department of Midwifery, Islamic Azad University, Estahban Branch, Estahban, IR Iran.
Int J Endocrinol Metab. 2014 Oct 1;12(4):e19378. doi: 10.5812/ijem.19378. eCollection 2014 Oct.
Maternal thyroid function alters during pregnancy. Inadequate adaptation to these changes results in thyroid dysfunction and pregnancy complications.
This prospective study aimed to evaluate the prevalence of thyroid diseases in pregnancy and its outcomes in south of Iran.
This prospective study was conducted on 600 healthy singleton pregnant women who aged 18 to 35 years old at 15 to 28 weeks of gestation. We investigated the prevalence of thyroid dysfunctions in women. Multivariate analysis was performed to determine the effect thyroid dysfunction on obstetric and neonatal outcome.
Thyroid stimulating hormone (TSH) levels of 0.51, 1.18, 1.68, 2.4, and 4.9 mIU/L were at 2.5th, 25th, 50th, 75th, and 97.5th percentile in our population. The prevalence of clinical hypothyroidism, subclinical hypothyroidism, overt hyperthyroidism, and subclinical hyperthyroidism in all pregnant women was 2.4%, 11.3%, 1.2%, and 0.3%, respectively. In addition, 1.4% of patients had isolated hypothyroxinemia. Clinical hypothyroidism was associated with increased risk of preterm delivery (P = 0.045). Subclinical hypothyroidism had a significant association with intrauterine growth restriction (IUGR) (P = 0.028) as well as low Apgar score at first minute (P = 0.022). Maternal hyperthyroidism was associated with IUGR (P = 0.048).
We revealed that thyroid dysfunction during pregnancy was associated with IUGR and low Apgar score even in subclinical forms. Further studies are required to determine whether early diagnosis and treatment of thyroid diseases, even in subclinical form, can prevent their adverse effect on fetus.
孕期母体甲状腺功能会发生变化。对这些变化适应不足会导致甲状腺功能障碍和妊娠并发症。
这项前瞻性研究旨在评估伊朗南部孕期甲状腺疾病的患病率及其结局。
这项前瞻性研究针对600名年龄在18至35岁、妊娠15至28周的健康单胎孕妇进行。我们调查了女性甲状腺功能障碍的患病率。进行多变量分析以确定甲状腺功能障碍对产科和新生儿结局的影响。
在我们的研究人群中，促甲状腺激素（TSH）水平为0.51、1.18、1.68、2.4和4.9 mIU/L分别处于第2.5、25、50、75和97.5百分位数。所有孕妇中临床甲状腺功能减退、亚临床甲状腺功能减退、显性甲状腺功能亢进和亚临床甲状腺功能亢进的患病率分别为2.4%、11.3%、1.2%和0.3%。此外，1.4%的患者有单纯低甲状腺素血症。临床甲状腺功能减退与早产风险增加相关（P = 0.
