高对映选择性钌（II）催化吲哚与炔烃的直接 C2-顺式烯丙基化反应。
Highly stereoselective ruthenium(II)-catalyzed direct C2-syn-alkenylation of indoles with alkynes.
机构信息
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
出版信息
Org Lett. 2015 Mar 20;17(6):1349-52. doi: 10.1021/ol503618m. Epub 2015 Mar 6.
PMID:25746416
Abstract
A carboamide-directed ruthenium-catalyzed C2-hydroindolation of alkynes has been described. This transformation provides a rapid access to free (N-H) C2-syn-alkenylated indole derivatives with the assistance of copper(II) salts, in which the directing group is removed via a one-pot process.
摘要
一种碳酰胺导向的钌催化炔烃 C2-氢吲哚化反应已经被描述。在铜(II)盐的协助下，该转化提供了一种快速获得游离（N-H）C2-顺式烯基化吲哚衍生物的方法，其中导向基团通过一锅法去除。
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