Schmitt E, Van Brandwijk R, Van Snick J, Siebold B, Rüde E
Institut für Immunologie der Johannes Gutenberg Universität, Mainz, FRG.
Eur J Immunol. 1989 Nov;19(11):2167-70. doi: 10.1002/eji.1830191130.
Several antigen-specific T cell lines were found to secrete a lymphokine upon activation by antigen or lectin that was provisionally termed T cell growth factor III (TCGF III) because it induced the proliferation of a CD4+ T cell clone independently from IL2 and IL4. Amino acid sequence analysis (and the functional properties of TCGF III) revealed that TCGF III was identical with a recently identified lymphokine termed P40. TCGF III/P40 was not only produced by long-term cultured T cell lines but also upon stimulation of freshly isolated Mlsa-reactive T cells. In addition, naive CD4+ T cells secreted TCGF III/P40 upon activation by lectin or allo-major histocompatibility complex structures. However, in spite of its growth-promoting activity for a CD4+ T cell clone this lymphokine does not appear to function as a general growth factor for T cells.
发现几种抗原特异性T细胞系在被抗原或凝集素激活后会分泌一种淋巴因子，该淋巴因子因能独立于白细胞介素2（IL2）和白细胞介素4（IL4）诱导CD4 + T细胞克隆增殖，故而被暂时命名为T细胞生长因子III（TCGF III）。氨基酸序列分析（以及TCGF III的功能特性）表明，TCGF III与最近鉴定出的一种名为P40的淋巴因子相同。TCGF III / P40不仅由长期培养的T细胞系产生，新鲜分离的Mlsa反应性T细胞受到刺激时也会产生。此外，幼稚CD4 + T细胞在被凝集素或同种异体主要组织相容性复合体结构激活后会分泌TCGF III / P40。然而，尽管这种淋巴因子对CD4 + T细胞克隆具有促生长活性，但它似乎并非T细胞的通用生长因子。
