Tsuruo T
Rinsho Ketsueki. 1989 Aug;30(8):1128-32.
One of the major problems in cancer chemotherapy is the development of drug resistance during treatment. The nature of drug resistance in cancer patients is complex. Recently, it has been found that tumor cells can acquire resistance to anticancer drugs. It is now generally accepted that drug resistance at the cellular level (cellular resistance) is also an important mechanism of drug resistance in patients. The elucidation of the resistance mechanisms has progressed well recently owing to the application of cellular and molecular techniques in addition to the usual biological and biochemical techniques. In this article, I describe the mechanisms of cellular resistance, especially those of multidrug resistance at the molecular level, and I also discuss possible approaches to overcoming drug resistance.
癌症化疗的主要问题之一是治疗期间出现耐药性。癌症患者耐药性的本质很复杂。最近发现肿瘤细胞可获得对抗癌药物的耐药性。目前普遍认为细胞水平的耐药性（细胞耐药性）也是患者耐药的重要机制。除了常用的生物学和生物化学技术外，由于细胞和分子技术的应用，耐药机制的阐明最近取得了很大进展。在本文中，我描述了细胞耐药的机制，尤其是分子水平的多药耐药机制，并且我还讨论了克服耐药性的可能方法。
