Tsuruo T
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo.
Gan To Kagaku Ryoho. 1988 Oct;15(10):2848-52.
One of the major problems in cancer chemotherapy is the development of drug resistance during treatment. In the treatment of tumors with antitumor agents, tumor cells can acquire resistance to the drugs. This type of resistance is called as acquired drug resistance and the acquired drug resistances is a major factor for limiting the clinical use of antitumor agents. The elucidation of the resistance mechanisms has progressed well recently owing to the application of cellular and molecular techniques in addition to the usual biological and biochemical techniques. In this article, the mechanisms of cellular resistance, especially those of multidrug resistance at a molecular level, and possible approaches to overcoming drug resistance are described and discussed.
癌症化疗的主要问题之一是治疗期间耐药性的产生。在用抗肿瘤药物治疗肿瘤时，肿瘤细胞会对这些药物产生耐药性。这种类型的耐药性被称为获得性耐药，而获得性耐药是限制抗肿瘤药物临床应用的一个主要因素。由于除了常规的生物学和生物化学技术外，细胞和分子技术的应用，耐药机制的阐明最近取得了很大进展。在本文中，将描述和讨论细胞耐药的机制，特别是分子水平上的多药耐药机制，以及克服耐药性的可能方法。
