Viskoper R J, Laszt A, Oren S, Hochberg Y, Villa Y, Drexler I, Bregman L, Mishal J
Neth J Med. 1989 Oct;35(3-4):185-91.
The antihypertensive efficacy and tolerability of two betablockers: atenolol and bopindolol, was compared in a group of 30 elderly subjects aged 64.8 +/- 4.6 years. The daily dose of the two agents was relatively low. Atenolol 50-100 mg and bopindolol 0.5-1.0 mg sufficed to cause reduction of DBP to the target of less than or equal to 95 mm Hg, when applied as monotherapy. This was achieved in 75% of cases with bopindolol and in 93% of cases with atenolol. Atenolol, 50-100 mg/dd, lowered blood pressure from 173.7 +/- 13.2/103.7 +/- 3.0 (weekly) to 155.5 +/- 16.5/86.5 +/- 8.2 mm Hg (week 12) (P less than 0.005) while bopindolol, 0.5-1.0 mg, lowered blood pressure from 171.6 +/- 11.3/104.1 +/- 3.6 to 158.7 +/- 20.9/86.1 +/- 6.0 mm Hg (P less than 0.005). Heart rate was reduced from 80.5 (week 4) to 66.7 +/- 7.3 (week 12) by atenolol (P less than 0.0001), and from 83.7 +/- 11.8 (week 4) to 71.1 +/- 7.5 (week 12) by bopindolol (P less than 0.0001). Between treatment differences: comparisons yielded P values which were not sufficiently low to reject the null hypothesis of no difference between the two treatments. Well-being and short-term memory were not affected by either agent and tolerability of both drugs was good. These findings demonstrate that both bopindolol and atenolol are useful agents for control of hypertension in the elderly.
在一组30名年龄为64.8±4.6岁的老年受试者中，比较了两种β受体阻滞剂阿替洛尔和波吲洛尔的降压疗效和耐受性。两种药物的日剂量相对较低。当作为单一疗法使用时，阿替洛尔50 - 100毫克和波吲洛尔0.5 - 1.0毫克足以使舒张压降至小于或等于95毫米汞柱的目标值。使用波吲洛尔的患者中75%达到此目标，使用阿替洛尔的患者中93%达到此目标。阿替洛尔，50 - 100毫克/日，使血压从173.7±13.2/103.7±3.0（第4周）降至155.5±16.5/86.5±8.2毫米汞柱（第12周）（P<0.005），而波吲洛尔，0.5 - 1.0毫克，使血压从171.6±11.3/104.1±3.6降至158.7±20.9/86.1±6.0毫米汞柱（P<0.005）。阿替洛尔使心率从80.5（第4周）降至66.7±7.3（第12周）（P<0.0001），波吲洛尔使心率从83.7±11.8（第4周）降至71.1±7.5（第12周）（P<0.0001）。治疗差异比较：所得P值不够低，无法拒绝两种治疗无差异的零假设。两种药物对幸福感和短期记忆均无影响，且两种药物的耐受性良好。这些发现表明，波吲洛尔和阿替洛尔都是控制老年人高血压的有效药物。
