原发性 HIV-1 感染时高可溶性 CD14 水平预示着更快的疾病进展。
High Soluble CD14 Levels at Primary HIV-1 Infection Predict More Rapid Disease Progression.
机构信息
INSERM, U1018, Epidemiology of HIV and STI, CESP; University Paris-Sud Department of Public Health and Epidemiology, Bicêtre Hospital, AP-HP.
INSERM 1012, Immune Response Regulation, HIV-1 and Autoimmunity, University Paris-Sud, Le Kremlin Bicêtre.
出版信息
J Infect Dis. 2015 Sep 15;212(6):909-13. doi: 10.1093/infdis/jiv145. Epub 2015 Mar 6.
The soluble CD14 (sCD14) level was found associated with mortality during the chronic phase of human immunodeficiency virus (HIV) infection. Here we assessed its prognostic value in 138 patients with primary HIV infection. Higher sCD14 levels were associated with death, from myocardial infarction, but this was based on 3 deaths only. Among 68 untreated patients, those with higher sCD14 levels had more rapid spontaneous CD4 cell decline during the first 18 months following primary infection. This association persisted after adjustment for age, the CD4 cell count, and HIV viral load at diagnosis.
可溶性 CD14（sCD14）水平与人类免疫缺陷病毒（HIV）感染的慢性期的死亡率相关。在这里，我们评估了它在 138 例原发性 HIV 感染患者中的预后价值。较高的 sCD14 水平与死亡相关，死于心肌梗死，但这仅基于 3 例死亡。在 68 例未经治疗的患者中，那些 sCD14 水平较高的患者在原发性感染后 18 个月内 CD4 细胞自然下降更快。这种关联在调整诊断时的年龄、CD4 细胞计数和 HIV 病毒载量后仍然存在。
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