Brew B J, Robertson K, Wright E J, Churchill M, Crowe S M, Cysique L A, Deeks S, Garcia J V, Gelman B, Gray L R, Johnson T, Joseph J, Margolis D M, Mankowski J L, Spencer B
Departments of Neurology, Immunology and Infectious Diseases and Peter Duncan Neurosciences Unit St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Victoria St, Darlinghurst, Sydney, Australia, 2010,
J Neurovirol. 2015 Jun;21(3):322-34. doi: 10.1007/s13365-015-0322-6. Epub 2015 Mar 7.
On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australia, and brought together investigators currently working on HIV eradication together with investigators who are working on the neurological complications of HIV. The purpose of the meeting was to bring the two fields of HIV eradication and HIV neurology together to foster dialogue and cross talk to move the eradication field forward in the context of issues relating to the brain as a potential reservoir of HIV. The outcomes of the symposium were that there was substantive but not definitive evidence for the brain as an HIV reservoir that will provide a challenge to HIV eradication. Secondly, the brain as a clinically significant reservoir for HIV is not necessarily present in all patients. Consequently, there is an urgent need for the development of biomarkers to identify and quantify the HIV reservoir in the brain. Lastly, when designing and developing eradication strategies, it is critical that approaches to target the brain reservoir be included.
2014年7月18日，美国国立精神卫生研究所与维泰凯医疗保健公司及勃林格殷格翰公司合作，主办了一场关于消除HIV及其对大脑影响的研讨会。该研讨会是第20届国际艾滋病大会的附属活动。会议在澳大利亚墨尔本举行，汇集了目前致力于消除HIV的研究人员以及研究HIV神经并发症的研究人员。会议的目的是将消除HIV和HIV神经学这两个领域结合起来，促进对话与交流，以便在大脑作为HIV潜在储存库的相关问题背景下推动消除HIV领域的发展。研讨会的成果是，有实质性但非确凿的证据表明大脑是HIV储存库，这将给消除HIV带来挑战。其次，并非所有患者的大脑都是具有临床意义的HIV储存库。因此，迫切需要开发生物标志物来识别和量化大脑中的HIV储存库。最后，在设计和制定消除策略时，纳入针对大脑储存库的方法至关重要。
