Thomson Cynthia J, Power Rebecca J, Carlson Scott R, Rupert Jim L, Michel Grégory
a School of Kinesiology , University of British Columbia , Vancouver , Canada.
J Sports Sci. 2015;33(18):1861-70. doi: 10.1080/02640414.2015.1020841. Epub 2015 Mar 9.
Athletes participating in high-risk sports consistently report higher scores on sensation-seeking measures than do low-risk athletes or non-athletic controls. To determine whether genetic variants commonly associated with sensation seeking were over-represented in such athletes, proficient practitioners of high-risk (n = 141) and low-risk sports (n = 132) were compared for scores on sensation seeking and then genotyped at 33 polymorphic loci in 14 candidate genes. As expected, athletes participating in high-risk sports score higher on sensation seeking than did low-risk sport athletes (P < .01). Genotypes were associated with high-risk sport participation for two genes (stathmin, (P = .004) and brain-derived neurotrophic factor (P = .03)) as well as when demographically matched subsets of the sport cohorts were compared (P < .05); however, in all cases, associations did not survive correction for multiple testing.
与低风险运动员或非运动员对照组相比，参与高风险运动的运动员在寻求刺激量表上的得分一直较高。为了确定与寻求刺激通常相关的基因变异在这类运动员中是否过度存在，对高风险运动（n = 141）和低风险运动（n = 132）的熟练从业者进行了寻求刺激得分的比较，然后在14个候选基因的33个多态位点进行基因分型。正如预期的那样，参与高风险运动的运动员在寻求刺激方面的得分高于低风险运动的运动员（P <.01）。两个基因（微管相关蛋白（P = .004）和脑源性神经营养因子（P = .03））的基因型与高风险运动参与相关，并且在对运动队列进行人口统计学匹配的亚组比较时也是如此（P <.05）；然而，在所有情况下，这些关联在多重检验校正后均不成立。
