Arslan Ayla
From the Faculty of Engineering and Natural Sciences, Genetics and Bioengineering Dept., International University of Sarajevo, Sarajevo, Bosnia and Herzegovina; and the Faculty of Engineering and Natural Sciences, Dept. of Molecular Biology and Genetics, Üsküdar University, Üsküdar, İstanbul, Turkey.
J Neuropsychiatry Clin Neurosci. 2015;27(2):81-92. doi: 10.1176/appi.neuropsych.13080185. Epub 2015 Mar 9.
The majority of neuropsychiatric disorders show a strong degree of heritability, yet little is known about molecular factors involved in the pathophysiology of diseases like schizophrenia. After a brief historical introduction into the current understanding of neuropsychiatric disorders, the aim of this study is to discuss imaging genetics as a strategy to explore the pathophysiology of neuropsychiatric disorders. The candidate gene approach of imaging genetics is used for validation/replication studies of genes, whereas the hypothesis-free, noncandidate gene approach appears to be a tool for gene discovery. Besides, integration of environmental factors into neuroimaging begins to converge on neuroimaging studies of genetic variation. In the light of data from other avenues such as animal experimentation, these developments show a model of interdisciplinary research, which may lead to identifying markers for neuropsychiatric disorders.
大多数神经精神疾病都表现出很强的遗传性，但对于精神分裂症等疾病病理生理学中涉及的分子因素却知之甚少。在对当前对神经精神疾病的认识进行简要的历史介绍之后，本研究的目的是讨论影像遗传学作为探索神经精神疾病病理生理学的一种策略。影像遗传学的候选基因方法用于基因的验证/复制研究，而无假设、非候选基因方法似乎是一种基因发现工具。此外，将环境因素纳入神经影像学研究开始与遗传变异的神经影像学研究相结合。根据动物实验等其他途径的数据，这些进展展示了一种跨学科研究模式，这可能会导致识别神经精神疾病的标志物。
