Katagiri Y, Naora K, Ichikawa N, Hayashibara M, Iwamoto K
Department of Pharmacy, Shimane Medical University Hospital, Izumo, Japan.
J Pharm Pharmacol. 1989 Oct;41(10):717-9. doi: 10.1111/j.2042-7158.1989.tb06349.x.
The possible pharmacokinetic interaction between a new quinolone and fenbufen was investigated by comparing the plasma concentration-time profiles and serum protein binding of ofloxacin, fenbufen and its active metabolite, felbinac, in rats. The rats were administered intravenous doses of ofloxacin (5 mg kg-1), fenbufen (10 mg kg-1) alone or concomitantly. The plasma elimination half-lives were about 55 min in both groups. A slight elevation of plasma concentration of ofloxacin and a small decrease of its total body clearance were observed after its coadministration with fenbufen. The extent of ofloxacin binding to rat serum tended to be slightly reduced by fenbufen which coexisted at relatively high concentrations. Plasma concentration-time curves, pharmacokinetic parameters and serum protein binding of fenbufen and felbinac were not affected by the coadministration with ofloxacin. These results suggest that any substantive pharmacokinetic interaction may be unlikely after the concomitant administration of ofloxacin and fenbufen.
通过比较氧氟沙星、芬布芬及其活性代谢物联苯乙酸在大鼠体内的血药浓度-时间曲线和血清蛋白结合率，研究了一种新型喹诺酮类药物与芬布芬之间可能存在的药代动力学相互作用。给大鼠静脉注射氧氟沙星（5mg/kg-1）、芬布芬（10mg/kg-1），单独给药或同时给药。两组的血浆消除半衰期均约为55分钟。氧氟沙星与芬布芬合用时，其血浆浓度略有升高，全身清除率略有降低。芬布芬在相对较高浓度下共存时，氧氟沙星与大鼠血清的结合程度有轻微降低的趋势。芬布芬和联苯乙酸的血药浓度-时间曲线、药代动力学参数及血清蛋白结合率不受与氧氟沙星合用的影响。这些结果表明，氧氟沙星与芬布芬同时给药后，不太可能发生任何实质性的药代动力学相互作用。
