Heiblig M, Bozzoli V, Saison J, Thomas X, De Croze D, Traverse-Glehen A, Cosmidis A, Chidiac C, Ferry T, Alanio A, Bienvenu A L, Dupont D, Ducastelle-Lepretre S, Michallet M, Ader F
Service d'Hématologie 1G, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre Bénite, France.
Mycoses. 2015 May;58(5):308-12. doi: 10.1111/myc.12305. Epub 2015 Mar 6.
Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino-orbito-cerebral H. aspergillata infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high-dose regimen of antifungal drugs.
曲霉状 Hormographiella 是侵袭性丝状突破性感染的罕见病原体，大多在接受棘白菌素治疗后出现。我们报告了一名中性粒细胞减少患者，该患者在接受经验性卡泊芬净治疗时发生了严重的鼻窦-眼眶-脑部曲霉状 Hormographiella 感染，通过联合手术清创和高剂量抗真菌药物联合治疗的积极策略成功得到控制。
