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1
Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication.
Mol Cell. 2015 Mar 19;57(6):1124-1132. doi: 10.1016/j.molcel.2015.01.043. Epub 2015 Mar 5.
2
Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling.
Genes Dev. 2018 Jun 1;32(11-12):822-835. doi: 10.1101/gad.308148.117. Epub 2018 Jun 13.
3
Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks.
DNA Repair (Amst). 2013 Oct;12(10):791-9. doi: 10.1016/j.dnarep.2013.07.009. Epub 2013 Aug 13.
4
Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.
Mol Cell Biol. 2004 Nov;24(22):10016-25. doi: 10.1128/MCB.24.22.10016-10025.2004.
5
Yet another job for Dna2: Checkpoint activation.
DNA Repair (Amst). 2015 Aug;32:17-23. doi: 10.1016/j.dnarep.2015.04.009. Epub 2015 May 1.
7
Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition.
Mol Biol Cell. 2015 Oct 1;26(19):3480-8. doi: 10.1091/mbc.E15-05-0259. Epub 2015 Aug 5.
8
Ddc2ATRIP promotes Mec1ATR activation at RPA-ssDNA tracts.
PLoS Genet. 2019 Aug 1;15(8):e1008294. doi: 10.1371/journal.pgen.1008294. eCollection 2019 Aug.
9
Phosphoregulation of the checkpoint kinase Mec1.
DNA Repair (Amst). 2023 Sep;129:103543. doi: 10.1016/j.dnarep.2023.103543. Epub 2023 Jul 17.
10
Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication.
Mol Cell. 2020 May 7;78(3):396-410.e4. doi: 10.1016/j.molcel.2020.02.021. Epub 2020 Mar 12.

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2
A novel lncRNA YIL163C enhances genomic stability and antifungal resistance via the DNA damage response in .
Front Microbiol. 2025 May 1;16:1571797. doi: 10.3389/fmicb.2025.1571797. eCollection 2025.
4
Profiling Tel1 signaling reveals a non-canonical motif targeting DNA repair and telomere control machineries.
J Biol Chem. 2025 Mar;301(3):108194. doi: 10.1016/j.jbc.2025.108194. Epub 2025 Jan 16.
6
Multi-step control of homologous recombination via Mec1/ATR suppresses chromosomal rearrangements.
EMBO J. 2024 Jul;43(14):3027-3043. doi: 10.1038/s44318-024-00139-9. Epub 2024 Jun 5.
7
Starting DNA Synthesis: Initiation Processes during the Replication of Chromosomal DNA in Humans.
Genes (Basel). 2024 Mar 14;15(3):360. doi: 10.3390/genes15030360.
9
Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress.
Wellcome Open Res. 2023 Jul 26;8:327. doi: 10.12688/wellcomeopenres.19617.1. eCollection 2023.

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1
Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.
Mol Cell. 2015 Jan 22;57(2):273-89. doi: 10.1016/j.molcel.2014.11.016. Epub 2014 Dec 18.
2
Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.
PLoS Genet. 2014 Feb 20;10(2):e1004136. doi: 10.1371/journal.pgen.1004136. eCollection 2014 Feb.
3
Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage.
Genes Dev. 2013 Sep 15;27(18):1999-2008. doi: 10.1101/gad.222992.113. Epub 2013 Sep 12.
5
Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery.
Genes Dev. 2013 Feb 1;27(3):313-21. doi: 10.1101/gad.204750.112. Epub 2013 Jan 25.
7
Replication stress and genome rearrangements: lessons from yeast models.
Curr Opin Genet Dev. 2013 Apr;23(2):132-9. doi: 10.1016/j.gde.2012.11.009. Epub 2012 Dec 22.
8
DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9.
Nature. 2013 Jan 3;493(7430):120-4. doi: 10.1038/nature11658. Epub 2012 Nov 18.
9
Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.
Mol Cell. 2010 Nov 12;40(3):353-63. doi: 10.1016/j.molcel.2010.10.017.
10
A proteome-wide analysis of kinase-substrate network in the DNA damage response.
J Biol Chem. 2010 Apr 23;285(17):12803-12. doi: 10.1074/jbc.M110.106989. Epub 2010 Feb 27.

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