Oriba H A, Maibach H I
Department of Dermatology, University of California, San Francisco.
Acta Derm Venereol. 1989;69(6):461-5.
The kinetics of water desorption after water loading was evaluated by means of transepidermal water loss (TEWL) decay curves. The effects of delipidation and ageing on the desorption of the water biomolecule was investigated in the vulva and on the forearm. All decay constants were analysed by curve stripping analysis and found to fit a bi-exponential decay. There was no significant difference in decay constant when compared by site. However, the terminal decay constant differed significantly after delipidation in both vulva and on forearm (p less than 0.02, p less than 0.04, respectively) in premenopausal women. Significant differences were also noted at post-menopausal forearm and vulva sites after delipidation for the terminal decay constant (p less than 0.006, p less than 0.02, respectively). Delipidation probably alters bound water in the process of sorption. Differences in decay constant when compared between pre- and post-menopausal women were noted only at the vulva for beta 1 decay constant (p less than 0.05). beta 2 of the forearm was not affected by menopause. Data are also presented to support the notion that structural lipids of the stratum corneum may have a water-holding property.
通过经表皮水分流失（TEWL）衰减曲线评估水负荷后水的解吸动力学。研究了去脂和老化对外阴及前臂水生物分子解吸的影响。所有衰减常数均通过曲线剥离分析进行分析，发现符合双指数衰减。按部位比较时，衰减常数无显著差异。然而，在绝经前女性中，去脂后外阴和前臂的终末衰减常数均有显著差异（分别为p<0.02，p<0.04）。去脂后绝经后前臂和外阴部位的终末衰减常数也有显著差异（分别为p<0.006，p<0.02）。去脂可能在吸附过程中改变结合水。绝经前和绝经后女性比较时，仅在外阴β1衰减常数有差异（p<0.05）。前臂的β2不受绝经影响。还提供了数据支持角质层结构脂质可能具有保水特性这一观点。
