Tagami H, Yoshikuni K
Arch Dermatol. 1985 May;121(5):642-5.
Scaly skin lesions are caused by decreased water content of the stratum corneum, despite the well-known fact that they usually show increased water passage. By performing simultaneous measurements of transepidermal water loss (TEWL) to check the water-barrier function of the stratum corneum and cutaneous conductance to the high-frequency electric current of 3.5 MHz, which is an indicator of skin-surface hydration state, in patients with psoriasis who had lesions of various grades of severity, we obtained data indicating that there is an inverse relationship between these functions of the stratum corneum. Furthermore, a time course study of TEWL and functional analysis of stratum corneum by an in vivo water sorption-desorption test performed on the experimentally induced scaly lesions after adhesive-tape stripping demonstrated that such pathologic stratum corneum is characterized by a water-holding defect that is associated with increased TEWL.
鳞状皮肤病变是由角质层含水量降低引起的，尽管众所周知它们通常表现出水分通过增加。通过对不同严重程度病变的银屑病患者同时测量经表皮水分流失（TEWL）以检查角质层的水屏障功能，以及测量皮肤对3.5MHz高频电流的传导率（这是皮肤表面水合状态的指标），我们获得的数据表明角质层的这些功能之间存在反比关系。此外，对胶带剥离后实验诱导的鳞状病变进行体内水吸附 - 解吸试验，对TEWL进行时间进程研究和角质层功能分析，结果表明这种病理性角质层的特征是与TEWL增加相关的持水缺陷。
