van Kemenade Patricia M, Houben Mark M J, Huyghe Jacques M, Douven Lucien F A
Personal Care Institute, Philips Research, Eindhoven, The Netherlands.
Skin Res Technol. 2004 May;10(2):109-12. doi: 10.1111/j.1600-0846.2004.00059.x.
BACKGROUND/PURPOSE: To describe the water and ion transport through the skin under different conditions, we developed a three-component mixture model. This model has proven to describe the transient change in transepidermal water loss (TEWL) after a change in relative humidity and the result of damage to the skin. Osmotic forces arc present in the model. To assess the influence of osmotic forces on the water uptake of the skin, we investigated transient TEWL values after 1 h application of salt solutions of different molarities (0, 1, and 4 M NaCl).
Filters saturated with 0, 1, and 4 M NaCl solution were applied for 1 h under occlusion. TEWL was measured 50-90 min after removal of the solution. The transient water loss curves were fit with an exponential function. The area under the fitted curve was calculated and regarded as a measure for the amount of extra water absorbed in the skin.
For all molarities, TEWL is increased immediately after removal of the solution. In time, this increase decays until pre-application values are reached again. The rate of decrease differs significantly for all three molarities. Ninety-five per cent of the increase has been reversed after 30, 19, and 6 min for the 0, 1, and 4 M case, respectively. The amount of water absorbed differs significantly between the three molarities 7.3+/-2.0; 3.9+/-1.0; 2.0+/-0.5 g/m(2), respectively.
In all cases, there was an increase in TEWL immediately after removal of the solution. The significant differences in decay time and amount of water absorbed between the three molarities indicate that osmotic forces do play an important role in the water uptake.
背景/目的：为了描述在不同条件下通过皮肤的水和离子转运，我们开发了一种三组分混合物模型。该模型已被证明能够描述相对湿度变化和皮肤受损后经表皮水分流失（TEWL）的瞬态变化。模型中存在渗透力。为了评估渗透力对皮肤水分吸收的影响，我们研究了在应用不同摩尔浓度（0、1和4 M NaCl）的盐溶液1小时后的瞬态TEWL值。
将用0、1和4 M NaCl溶液饱和的滤片在封闭条件下应用1小时。在去除溶液后50 - 90分钟测量TEWL。将瞬态水分流失曲线用指数函数拟合。计算拟合曲线下的面积，并将其视为皮肤中额外吸收水量的一种度量。
对于所有摩尔浓度，在去除溶液后TEWL立即增加。随着时间推移，这种增加逐渐衰减，直到再次达到应用前的值。对于所有三种摩尔浓度，下降速率有显著差异。对于0、1和4 M的情况，分别在30、19和6分钟后，95%的增加已被逆转。三种摩尔浓度之间吸收的水量有显著差异，分别为7.3±2.0；3.9±1.0；2.0±0.5 g/m²。
在所有情况下，去除溶液后TEWL立即增加。三种摩尔浓度在衰减时间和吸收水量上的显著差异表明渗透力在水分吸收中确实起着重要作用。
