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韩国胃癌腹腔镜手术随机对照试验的现状

Current status of randomized controlled trials for laparoscopic gastric surgery for gastric cancer in Korea.

作者信息

Byun Cheulsu, Han Sang-Uk

机构信息

Department of Surgery, School of Medicine, Ajou University, Suwon, Korea.

出版信息

Asian J Endosc Surg. 2015 May;8(2):130-8. doi: 10.1111/ases.12176. Epub 2015 Mar 5.

DOI:10.1111/ases.12176
PMID:25753372
Abstract

Laparoscopic gastrectomy for gastric cancer has rapidly gained popularity as a result of the increased incidence of early gastric cancer in Korea. Although laparoscopic gastrectomy has been considered as an investigational treatment because of the lack of solid evidence of efficacy and safety, it is increasingly regarded as a standard treatment for early gastric cancer. Moreover, solid evidence is anticipated from two studies in Korea, KLASS 01 and KLASS 02, the latter of which examines the suitability of laparoscopic gastrectomy for advanced gastric cancer. The use of cutting-edge techniques for laparoscopic gastrectomy enables surgeons to deliver various treatment options that offer the best possible quality of life after gastrectomy. In this review, we summarize the current status of clinical trials on laparoscopic gastrectomy in Korea and examine future perspectives regarding laparoscopic gastrectomy for the treatment of gastric cancer.

摘要

由于韩国早期胃癌发病率的上升,腹腔镜胃癌切除术迅速受到欢迎。尽管由于缺乏疗效和安全性的确凿证据,腹腔镜胃癌切除术一直被视为一种试验性治疗方法,但它越来越被视为早期胃癌的标准治疗方法。此外,预计韩国的两项研究KLASS 01和KLASS 02将提供确凿证据,后者研究腹腔镜胃癌切除术对进展期胃癌的适用性。腹腔镜胃癌切除术采用前沿技术,使外科医生能够提供各种治疗选择,从而在胃癌切除术后提供尽可能最佳的生活质量。在本综述中,我们总结了韩国腹腔镜胃癌切除术的临床试验现状,并探讨了腹腔镜胃癌切除术治疗胃癌的未来前景。

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引用本文的文献

1
Morbidity and Mortality of Laparoscopic vs Open Total Gastrectomy for Clinical Stage I Gastric Cancer: The CLASS02 Multicenter Randomized Clinical Trial.腹腔镜与开腹全胃切除术治疗临床Ⅰ期胃癌的发病率和死亡率:CLASS02 多中心随机临床试验。
JAMA Oncol. 2020 Oct 1;6(10):1590-1597. doi: 10.1001/jamaoncol.2020.3152.
2
Pylorus-preserving gastrectomy for early cancer involving the upper third: can we go higher?保留幽门的胃切除术治疗上三分之一早期癌症:能否再高一些?
Gastric Cancer. 2019 Jul;22(4):881-891. doi: 10.1007/s10120-018-00921-9. Epub 2019 Feb 19.
3
Study on safety of laparoscopic total gastrectomy for clinical stage I gastric cancer: the protocol of the CLASS02-01 multicenter randomized controlled clinical trial.
腹腔镜全胃切除术治疗临床Ⅰ期胃癌安全性的研究:CLASS02-01 多中心随机对照临床试验方案。
BMC Cancer. 2018 Oct 3;18(1):944. doi: 10.1186/s12885-018-4846-z.
4
Minimally invasive surgery for upper gastrointestinal cancer: Our experience and review of the literature.上消化道癌的微创手术:我们的经验及文献综述
World J Gastroenterol. 2016 May 21;22(19):4626-37. doi: 10.3748/wjg.v22.i19.4626.