Zhu Chunchao, Zhao Gang, Cao Hui
Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2018 Feb 25;21(2):154-159.
Laparoscopic technology is gradually accepted in gastric cancer surgery, whose efficacy has been demonstrated by some clinical researches. Randomized controlled trials (RCT) are considered as the most important evidence to prove clinical outcomes of laparoscopic surgery for gastric cancer. Korean gastric surgeons have made great contributions to RCT in laparoscopic gastric cancer surgery. KLASS (Korean Laparoscopic Gastrointestinal Surgery Study Group) is one of the most important forerunner and global leader of clinical trials of gastric cancer treatment. KLASS series clinical trials are attracting global attention because of the significant value of surgical treatment for gastric cancer. The RCTs in Korea involve in many aspects of laparoscopic gastrectomy for gastric cancer, including laparoscopy application in early gastric cancer (KLASS-01, KLASS-03 and KLASS-07), advanced gastric cancer (KLASS-02 and KLASS-06), function-preserving gastrectomy (KLASS-04,KLASS-05) and sentinel node navigation surgery (SENORITA trial). In order to share some informations of these RCTs, we review and prospect some important clinical trials of laparoscopic gastric cancer surgery in Korea. With the experience of Korean gastric surgeons, we can make more progress in our own clinical trials of laparoscopic gastric cancer surgery.
腹腔镜技术在胃癌手术中逐渐被接受，一些临床研究已证实了其疗效。随机对照试验（RCT）被认为是证明腹腔镜胃癌手术临床疗效的最重要证据。韩国胃肠外科医生在腹腔镜胃癌手术的随机对照试验方面做出了巨大贡献。韩国腹腔镜胃肠手术研究组（KLASS）是胃癌治疗临床试验最重要的先驱者和全球领导者之一。KLASS系列临床试验因其对胃癌手术治疗的重大价值而备受全球关注。韩国的随机对照试验涉及腹腔镜胃癌切除术的诸多方面，包括腹腔镜在早期胃癌（KLASS - 01、KLASS - 03和KLASS - 07）、进展期胃癌（KLASS - 02和KLASS - 06）、保留功能的胃切除术（KLASS - 04、KLASS - 05）以及前哨淋巴结导航手术（SENORITA试验）中的应用。为了分享这些随机对照试验的一些信息，我们对韩国腹腔镜胃癌手术的一些重要临床试验进行回顾和展望。借鉴韩国胃肠外科医生的经验，我们在自己的腹腔镜胃癌手术临床试验中可以取得更大的进展。
