线粒体自噬：BNIP3和NIX的起源、意义及作用

Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX.

作者信息

Ney Paul A

机构信息

Department of Cell & Molecular Biology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 East 67 Street, New York, NY 10065-6275, USA.

出版信息

Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2775-83. doi: 10.1016/j.bbamcr.2015.02.022. Epub 2015 Mar 6.

DOI:10.1016/j.bbamcr.2015.02.022

PMID:25753537

Abstract

Mitochondrial autophagy (mitophagy) is a core cellular activity. In this review, we consider mitophagy and related cellular processes and discuss their significance for human disease. Strong parallels exist between mitophagy and xenophagy employed in host defense. These mechanisms converge on receptors in the innate immune system in clinically relevant scenarios. Mitophagy is part of a cellular quality control mechanism, which is implicated in degenerative disease, especially neurodegenerative disease. Furthermore, mitophagy is an aspect of cellular remodeling, which is employed during development. BNIP3 and NIX are related multi-functional outer mitochondrial membrane proteins. BNIP3 regulates mitophagy during hypoxia, whereas NIX is required for mitophagy during development of the erythroid lineage. Recent advances in the field of BNIP3- and NIX-mediated mitophagy are discussed.

摘要

线粒体自噬是一种核心细胞活动。在本综述中，我们探讨线粒体自噬及相关细胞过程，并讨论它们对人类疾病的意义。线粒体自噬与宿主防御中采用的异源自噬存在显著相似之处。在临床相关情况下，这些机制在固有免疫系统中汇聚于受体。线粒体自噬是细胞质量控制机制的一部分，这与退行性疾病尤其是神经退行性疾病有关。此外，线粒体自噬是细胞重塑的一个方面，在发育过程中发挥作用。BNIP3和NIX是相关的多功能线粒体外膜蛋白。BNIP3在缺氧时调节线粒体自噬，而NIX在红系谱系发育过程中是线粒体自噬所必需的。本文讨论了BNIP3和NIX介导的线粒体自噬领域的最新进展。