Xiao Mengsu, Jiang Yuxin, Zhu Qingli, You Shanshan, Li Jianchu, Wang Hongyan, Lai Xingjian, Zhang Jing, Liu He, Zhang Jing
Department of Diagnostic Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1, Dongcheng District, Beijing 100730, China.
Department of Diagnostic Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1, Dongcheng District, Beijing 100730, China.
Acad Radiol. 2015 Apr;22(4):439-46. doi: 10.1016/j.acra.2014.12.012.
Diffuse optical tomography (DOT) is an emerging functional modality, which can reflect tumor metabolic activity and angiogenesis. The purpose of this exploratory study was to correlate the total hemoglobin concentration (THC) measured by noninvasive DOT with prognostic factors in breast carcinomas.
We prospectively imaged 251 breast carcinomas in 229 consecutive women (mean age, 51.18 ± 12.32 years) using DOT from 2007 to 2010. Tumor angiogenesis and metabolic activity were assessed based on quantitatively measured THC. The THC was correlated with prognostic factors, including tumor size, histopathologic classification, histologic grade, estrogen receptor (ER), progesterone receptor (PR), c-erbB-2, and p53.
In univariate analysis, THC was significantly correlated with the following prognostic factors: tumor size (P < .001), histologic grade (P < .001), ER (P < .05), PR (P < .001), and c-erbB-2 (P < .05). THC was not associated with histopathologic classification (P = .170) or p53 (P = .463). On the basis of a stepwise multiple regression analysis, THC of invasive ductal carcinoma was significantly correlated with tumor size (P < .001), histologic grade (P < .001), and PR (P < .05).
THC was associated with prognostic factors of breast carcinoma. THC may be considered as a new prognostic parameter of breast carcinoma and a prediction of tumor behavior and biological activity.
扩散光学断层扫描（DOT）是一种新兴的功能成像方式，可反映肿瘤代谢活性和血管生成情况。本探索性研究旨在将无创DOT测量的总血红蛋白浓度（THC）与乳腺癌的预后因素相关联。
2007年至2010年期间，我们对229名连续女性（平均年龄51.18±12.32岁）中的251例乳腺癌进行了DOT前瞻性成像。基于定量测量的THC评估肿瘤血管生成和代谢活性。将THC与预后因素相关联，这些因素包括肿瘤大小、组织病理学分类、组织学分级、雌激素受体（ER）、孕激素受体（PR）、c-erbB-2和p53。
在单因素分析中，THC与以下预后因素显著相关：肿瘤大小（P <.001）、组织学分级（P <.001）、ER（P <.05）、PR（P <.001）和c-erbB-2（P <.05）。THC与组织病理学分类（P =.170）或p53（P =.463）无关。基于逐步多元回归分析，浸润性导管癌的THC与肿瘤大小（P <.001）、组织学分级（P <.001）和PR（P <.05）显著相关。
THC与乳腺癌的预后因素相关。THC可被视为乳腺癌的一个新的预后参数，并可用于预测肿瘤行为和生物学活性。
