Ranzinger René, York William S
Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA, 30602-4712, USA,
Methods Mol Biol. 2015;1273:109-24. doi: 10.1007/978-1-4939-2343-4_8.
Over the last two decades, several carbohydrate structure databases have been developed and made publicly available by different research groups around the world. This led to the fragmentation of information about carbohydrate structures into different resources that have no or only weak interaction with each other. GlycomeDB was developed to integrate the carbohydrate structures from different resources by generating a single-indexed catalog of these structures that associates each structure with its reference in the original resources. GlycomeDB facilitates searching for carbohydrate structures in all the integrated resources by eliminating the need to use several different search interfaces and manually integrating the results. References provided by GlycomeDB make it possible to retrieve information that is beyond the scope of GlycomeDB but present in the integrated databases. This chapter illustrates the use of the GlycomeDB search interfaces and web services by way of three example cases.
在过去二十年中,世界各地的不同研究小组开发并公开了几个碳水化合物结构数据库。这导致了关于碳水化合物结构的信息分散到不同的资源中,这些资源之间没有或只有微弱的相互作用。GlycomeDB的开发目的是通过生成这些结构的单索引目录,将来自不同资源的碳水化合物结构整合起来,该目录将每个结构与其在原始资源中的参考文献相关联。GlycomeDB通过消除使用多个不同搜索界面并手动整合结果的需求,方便在所有整合资源中搜索碳水化合物结构。GlycomeDB提供的参考文献使得检索超出GlycomeDB范围但存在于整合数据库中的信息成为可能。本章通过三个示例案例来说明GlycomeDB搜索界面和网络服务的使用。