Kumagai Hiroshi, Zempo-Miyaki Asako, Yoshikawa Toru, Tsujimoto Takehiko, Tanaka Kiyoji, Maeda Seiji
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Endocr J. 2015;62(5):423-30. doi: 10.1507/endocrj.EJ14-0555. Epub 2015 Mar 1.
Obesity has reached global epidemic proportions and is associated with multiple comorbidities, including cardiovascular disease. A novel predictor of cardiovascular disease is elevated central systolic blood pressure. In fact, lifestyle modifications have been shown to decrease the central systolic blood pressure in overweight and obese men. The mechanism underlying these changes has yet to be fully elucidated. Interestingly, testosterone has been found to have cardioprotective effects. Moreover, serum testosterone levels are lower in obese men than in normal weight men. However, it is still unclear whether testosterone participates in the decrease of central blood pressure in overweight and obese men following lifestyle modifications. So, the purpose of the present study was to investigate the effect of testosterone on central systolic blood pressure in overweight and obese men before and after the 12-week lifestyle modification program. Forty-four overweight and obese men completed a 12-week lifestyle modification program (aerobic exercise training and dietary modifications). For all participants, central systolic blood pressure and serum testosterone levels were measured before and after the program. After the program, central systolic blood pressure was significantly decreased while serum total testosterone levels were significantly increased in overweight and obese men. Moreover, we also found a significant negative relationship between the change in serum testosterone levels and that in central systolic blood pressure. The present study suggests that increased serum testosterone levels likely contribute to a decrease in central blood pressure in overweight and obese men.
肥胖已达到全球流行程度，并与多种合并症相关，包括心血管疾病。心血管疾病的一种新的预测指标是中心收缩压升高。事实上，生活方式的改变已被证明可降低超重和肥胖男性的中心收缩压。这些变化背后的机制尚未完全阐明。有趣的是，已发现睾酮具有心脏保护作用。此外，肥胖男性的血清睾酮水平低于正常体重男性。然而，睾酮是否参与超重和肥胖男性生活方式改变后中心血压的降低仍不清楚。因此，本研究的目的是调查睾酮对超重和肥胖男性在为期12周的生活方式改变计划前后中心收缩压的影响。44名超重和肥胖男性完成了为期12周的生活方式改变计划（有氧运动训练和饮食调整）。对所有参与者在计划前后测量中心收缩压和血清睾酮水平。计划结束后，超重和肥胖男性的中心收缩压显著降低，而血清总睾酮水平显著升高。此外，我们还发现血清睾酮水平的变化与中心收缩压的变化之间存在显著的负相关关系。本研究表明，血清睾酮水平升高可能有助于降低超重和肥胖男性的中心血压。
