抗癌药物对人类多药耐药基因（MDR1）的直接激活作用。
The direct activation of human multidrug resistance gene (MDR1) by anticancer agents.
作者信息
Kohno K, Sato S, Takano H, Matsuo K, Kuwano M
机构信息
Department of Biochemistry, Oita Medical School, Japan.
出版信息
Biochem Biophys Res Commun. 1989 Dec 29;165(3):1415-21. doi: 10.1016/0006-291x(89)92761-7.
Enhanced expression of a multidrug-resistance gene (MDR1) is observed in some cancer patient, but any regulatory mechanisms of MDR1 gene expression in this phenomenon is not yet known. In this study, the regulation of MDR1 gene was analysed by transient expression assays in the presence of anticancer agents. We found that MDR1 promoter could be activated directly on the addition of anticancer agents including vincristine, daunomycin, adriamycin and colchicine. The results suggest that the level of MDR1 mRNA expression is associated with previous chemotherapy, including drugs that select the multidrug resistance phenotype.
在一些癌症患者中观察到多药耐药基因（MDR1）的表达增强，但这种现象中MDR1基因表达的任何调控机制尚不清楚。在本研究中，通过在抗癌药物存在的情况下进行瞬时表达分析来分析MDR1基因的调控。我们发现，加入包括长春新碱、柔红霉素、阿霉素和秋水仙碱在内的抗癌药物后，MDR1启动子可被直接激活。结果表明，MDR1 mRNA表达水平与先前的化疗有关，包括选择多药耐药表型的药物。
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