Bakheet Kholoud Mohammed A, Alghanemi Rand G, Alsiyoufi Alya M, Abduljabbar Mohammed, Hariri Jehad
Dermatology, King Abdulaziz University, Jeddah, SAU.
Dermatology, King Abdulaziz University Hospital, Jeddah, SAU.
Cureus. 2020 Dec 18;12(12):e12148. doi: 10.7759/cureus.12148.
Background Acne vulgaris is one of the most common diseases worldwide. It is a chronic, relapsing inflammatory skin disease. Nearly anyone can be affected at any age. Adolescents and young adults are more susceptible, with a prevalence as high as 35% to 90% and reaching up to 100% in both sexes. Isotretinoin is the most effective medication to be used. It has been reported in the literature that many populations are non-adherents to or aware of safety recommendations. This study aims to assess females' awareness and safety of isotretinoin use in the western region of Saudi Arabia. Methods This is a cross-sectional, descriptive study. A semi-structured questionnaire was used, data was collected from an electronic validated survey and published on a social platform. Statistical analysis was conducted with the aid of Statistical Package for Social Sciences (SPSS) version 21 (IBM Corp., Armonk, NY, USA). Results The total number of included responses was 1066. Most of the participants were 12-22 years old (45.2%), single (72.2%) and had a bachelor's degree (69.6%). Among the total number of participants there were 285 participants who used isotretinoin. Ninety-three percent of them had a prescription of isotretinoin from a physician. The common dose given was approximately 20 mg and the common duration was more than six months. Conclusion There is a good amount of knowledge in our population regarding isotretinoin side effects, although only half of them were informed about them by their treating physicians. We noticed an obvious lack of awareness about safe practice during childbearing age and marriage. This highlights the need for optimal education by health care providers and the role of media is obvious to improve their practices and hopefully decrease the risks as it was the second most common source of information after dermatologists in our population. Also we recommend paying more attention to the psychological side effect which was reported by 9% of our participants.
背景 寻常痤疮是全球最常见的疾病之一。它是一种慢性、复发性炎症性皮肤病。几乎任何人在任何年龄都可能受到影响。青少年和年轻人更容易患病，患病率高达35%至90%，男女患病率均可达100%。异维A酸是最有效的治疗药物。文献报道，许多人群不遵守或不了解安全建议。本研究旨在评估沙特阿拉伯西部地区女性对异维A酸使用的认知及安全性。方法 这是一项横断面描述性研究。使用了半结构化问卷，数据从电子验证调查中收集并发布在一个社交平台上。借助社会科学统计软件包（SPSS）21版（美国纽约州阿蒙克市IBM公司）进行统计分析。结果 纳入的回复总数为1066份。大多数参与者年龄在12至22岁之间（45.2%），单身（72.2%），拥有学士学位（69.6%）。在参与者总数中，有285名参与者使用过异维A酸。其中93%的人有医生开具的异维A酸处方。常用剂量约为20毫克，常用疗程超过六个月。结论 我们的人群对异维A酸的副作用有一定的了解，尽管只有一半的人是由治疗医生告知的。我们注意到在育龄期和婚姻期间对安全做法的认识明显不足。这凸显了医疗保健提供者进行优化教育的必要性，而且媒体的作用很明显，它是我们人群中仅次于皮肤科医生的第二大常见信息来源，有助于改善他们的做法并有望降低风险。此外，我们建议更多关注9%的参与者报告的心理副作用。
