Garba Munir, Khabour Omar F, Alzoubi Karem H, Abu-Siniyeh Ahmed, Al-Qarqaz Firas
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Dermatol Res Pract. 2020 Apr 29;2020:3176521. doi: 10.1155/2020/3176521. eCollection 2020.
Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment.
In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients ( = 230).
Several biochemical parameters were measured at baseline and after treatments with isotretinoin. The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients.
Alterations in lipid profile with a significant increase of ALT (=0.007) were detected after isotretinoin treatment. Moreover, percentage change in HDL following isotretinoin treatment was significantly associated with rs1501299 (=0.008). On the other hand, no associations between examined SNPs and side effects of isotretinoin and other lipid parameters (total cholesterol, LDL, and triglycerides) or liver function enzymes (ALT and AST) were detected.
Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.
痤疮是一种常见的毛囊皮脂腺疾病，尤其在年轻人中高发。临床上，治疗中度至重度痤疮最常用的药物是口服异维A酸。然而，异维A酸治疗反应存在个体差异，且该治疗会出现许多副作用，如肌肉骨骼疼痛、头痛和血脂改变。
本研究调查了脂联素基因的rs2241766和rs1501299基因多态性对异维A酸治疗的年轻成年痤疮患者（n = 230）副作用的影响。
在基线和异维A酸治疗后测量了多项生化参数。对230例患者进行了ADIPOQ基因单核苷酸多态性rs2241766和rs1501299的基因分型。
异维A酸治疗后检测到血脂改变，谷丙转氨酶显著升高（P = 0.007）。此外，异维A酸治疗后高密度脂蛋白的百分比变化与rs1501299显著相关（P = 0.008）。另一方面，未检测到所研究的单核苷酸多态性与异维A酸副作用及其他血脂参数（总胆固醇、低密度脂蛋白和甘油三酯）或肝功能酶（谷丙转氨酶和谷草转氨酶）之间存在关联。
目前的研究结果表明，ADIPOQ基因的rs1501299可能与异维A酸治疗后的痤疮患者高密度脂蛋白水平变化有关。
