将ω-芋螺毒素GVIA局部应用于豚鼠离体输精管的交感神经末梢。
Local application of omega-conotoxin GVIA to sympathetic nerve terminals in the guinea-pig isolated vas deferens.
作者信息
Brock J A, Cunnane T C, Ziogas J
机构信息
University Department of Pharmacology, Oxford.
出版信息
Br J Pharmacol. 1989 Dec;98 Suppl:775P.
Staphylococcus aureus 502A was grown in the presence of one-third of the minimal inhibitory concentration of clindamycin. Phagocytosis of the antibiotic-treated bacteria by human polymorphonuclear leukocytes was significantly enhanced, compared with that of the untreated control (P less than 0.001). Study of opsonization kinetics by a chemiluminescence assay demonstrated that clindamycin-treated staphylococci were opsonized more rapidly than control bacteria and that the serum concentration required for sufficient opsonization was lower. Complement was consumed much faster, and the opsonic fragment C3b was fixed more rapidly to the bacterial surface when the staphylococci were preincubated with clindamycin. Electron micrographs showed an alteration of the staphylococcal cell wall after clindamycin treatment.
金黄色葡萄球菌502A在克林霉素最低抑菌浓度的三分之一的条件下生长。与未处理的对照相比，人多形核白细胞对经抗生素处理的细菌的吞噬作用显著增强（P小于0.001）。通过化学发光测定法对调理作用动力学的研究表明，经克林霉素处理的葡萄球菌比对照细菌更快地被调理，并且充分调理所需的血清浓度更低。当葡萄球菌与克林霉素预孵育时，补体消耗得更快，调理片段C3b更快地固定在细菌表面。电子显微镜照片显示克林霉素处理后葡萄球菌细胞壁发生了改变。
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